New natural products as new leads for antibacterial drug discovery

被引：148
|
作者：
Brown, Dean G. [1 ]
Lister, Troy [1 ]
May-Dracka, Tricia L. [1 ]
机构：
[1] AstraZeneca, Waltham, MA 02451 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 02期
关键词：
Natural products; Antibacterial; Antimicrobial; SPHEROPLAST-FORMING ACTIVITY; SIGNAL PEPTIDASE; BACTERIAL RIBOSOME; ANTI-MRSA; ANTIBIOTICS; INHIBITION; GLOBOMYCIN; TARGET; STREPTOMYCES; TAXONOMY;
D O I：
10.1016/j.bmcl.2013.12.059
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes and the mechanisms by which they work. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：413 / 418
页数：6
相关论文
共 50 条
  • [21] Venomics: a new paradigm for natural products-based drug discovery
    Vetter, Irina
    Davis, Jasmine L.
    Rash, Lachlan D.
    Anangi, Raveendra
    Mobli, Mehdi
    Alewood, Paul F.
    Lewis, Richard J.
    King, Glenn F.
    AMINO ACIDS, 2011, 40 (01) : 15 - 28
  • [22] Are we seeing a resurgence in the use of natural products for new drug discovery?
    Li, Feng
    Wang, Yongli
    Li, Dapeng
    Chen, Yilun
    Dou, Q. Ping
    EXPERT OPINION ON DRUG DISCOVERY, 2019, 14 (05) : 417 - 420
  • [23] Special Issue on New Drug Discovery from Natural Products PREFACE
    Bhutani, K. K.
    INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, 48 (03) : 187 - 188
  • [24] Natural products from cyanobacteria: Exploiting a new source for drug discovery
    Sielaff, H
    Christiansen, G
    Schwecke, T
    IDRUGS, 2006, 9 (02) : 119 - 127
  • [25] Venomics: a new paradigm for natural products-based drug discovery
    Irina Vetter
    Jasmine L. Davis
    Lachlan D. Rash
    Raveendra Anangi
    Mehdi Mobli
    Paul F. Alewood
    Richard J. Lewis
    Glenn F. King
    Amino Acids, 2011, 40 : 15 - 28
  • [26] Special Issue on New Drug Discovery from Natural Products Foreword
    Kingston, David G. I.
    INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, 48 (03) : 185 - 186
  • [27] New drug discovery and development from natural products: Advances and strategies
    Wang, Yixin
    Wang, Fan
    Liu, Wenxiu
    Geng, Yifei
    Shi, Yahong
    Tian, Yu
    Zhang, Bin
    Luo, Yun
    Sun, Xiaobo
    PHARMACOLOGY & THERAPEUTICS, 2024, 264
  • [28] Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria
    Alvarez-Bardon, Maria
    Perez-Pertejo, Yolanda
    Ordonez, Cesar
    Sepulveda-Crespo, Daniel
    Carballeira, Nestor M.
    Tekwani, Babu L.
    Murugesan, Sankaranarayanan
    Martinez-Valladares, Maria
    Garcia-Estrada, Carlos
    Reguera, Rosa M.
    Balana-Fouce, Rafael
    MARINE DRUGS, 2020, 18 (04)
  • [29] Innovative strategies for chemo-diversification of natural products and discovery of potential new leads
    Gindro, K.
    Righi, D.
    Huber, R.
    Marcourt, L.
    Schnee, S.
    Wolfender, J-L
    Queiroz, E. F.
    PLANTA MEDICA, 2019, 85 (18) : 1418 - 1418
  • [30] Drugs from the Oceans: Marine Natural Products as Leads for Drug Discovery
    Altmann, Karl-Heinz
    CHIMIA, 2017, 71 (10) : 646 - 652
12345