New natural products as new leads for antibacterial drug discovery

被引：149
|
作者：
Brown, Dean G. [1 ]
Lister, Troy [1 ]
May-Dracka, Tricia L. [1 ]
机构：
[1] AstraZeneca, Waltham, MA 02451 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 02期
关键词：
Natural products; Antibacterial; Antimicrobial; SPHEROPLAST-FORMING ACTIVITY; SIGNAL PEPTIDASE; BACTERIAL RIBOSOME; ANTI-MRSA; ANTIBIOTICS; INHIBITION; GLOBOMYCIN; TARGET; STREPTOMYCES; TAXONOMY;
D O I：
10.1016/j.bmcl.2013.12.059
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes and the mechanisms by which they work. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：413 / 418
页数：6
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