New natural products as new leads for antibacterial drug discovery

被引：152

作者：

Brown, Dean G. ^{[1
]}

Lister, Troy ^{[1
]}

May-Dracka, Tricia L. ^{[1
]}

机构：

[1] AstraZeneca, Waltham, MA 02451 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 02期

关键词：

Natural products; Antibacterial; Antimicrobial; SPHEROPLAST-FORMING ACTIVITY; SIGNAL PEPTIDASE; BACTERIAL RIBOSOME; ANTI-MRSA; ANTIBIOTICS; INHIBITION; GLOBOMYCIN; TARGET; STREPTOMYCES; TAXONOMY;

D O I：

10.1016/j.bmcl.2013.12.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes and the mechanisms by which they work. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

引用

页码：413 / 418

页数：6

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