Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats

被引：22
作者：
Suzuki, M
Nishina, M
Endo, M
Matsushita, K
Tetsuka, M
Shima, K
Okuyama, S
机构：
[1] SAITAMA MED SCH,DEPT MED ZOOL,MOROYAMA,SAITAMA 35004,JAPAN
[2] NATL DEF MED COLL,DEPT NEUROSURG,TOKOROZAWA,SAITAMA 359,JAPAN
[3] TAISHO PHARMACEUT CO LTD,MED RES LABS,OMIYA,SAITAMA 330,JAPAN
来源：
GENERAL PHARMACOLOGY | 1997年 / 28卷 / 01期
关键词：
closed head injury; free magnesium; VA-045; P-31-NMR; rat brain;
D O I：
10.1016/S0306-3623(96)00148-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. We examined the alterations in cerebral free Mg2+ concentration in closed head in jury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo P-31-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it. Copyright (C) 1997 Elsevier Science Inc.
引用
收藏
页码：119 / 121
页数：3
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