Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer

被引：35
作者：
Patrignani, P [1 ]
机构：
[1] G Dannunzio Univ Chieti, Sch Med, Dept Med & Aging, Div Pharmacol, I-66013 Chieti, Italy
来源：
TOXICOLOGY LETTERS | 2000年 / 112卷
关键词：
cyclooxygenase-2; colorectal cancer; nonsteroidal anti-inflammatory drugs; specific COX-2 inhibitors;
D O I：
10.1016/S0378-4274(99)00210-6
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of colorectal cancer. Moreover, the NSAID sulindac reduces the number and size of polyps in patients with familial adenomatous polyposis. The mechanisms of these effects of NSAIDs are not known but several lines of evidence suggest the involvement of the inhibition of the inducible isoform of prostaglandin H synthase (known as COX-2). Specific COX-2 inhibitors, showing an improved profile of gastrointestinal safety vis-a-vis conventional NSAIDs, provide interesting tools to probe the COX-2 dependence of the apparent protection against colorectal cancer associated with the use of NSAIDs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：493 / 498
页数：6
相关论文
共 31 条
[1]  
Catella-Lawson F, 1999, J PHARMACOL EXP THER, V289, P735
[2]   Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina [J].
Cipollone, F ;
Patrignani, P ;
Greco, A ;
Panara, MR ;
Padovano, R ;
Cuccurullo, F ;
Patrono, C ;
Rebuzzi, AG ;
Liuzzo, G ;
Quaranta, G ;
Maseri, A .
CIRCULATION, 1997, 96 (04) :1109-1116
[3]   Cyclooxygenase in biology and disease [J].
Dubois, RN ;
Abramson, SB ;
Crofford, L ;
Gupta, RA ;
Simon, LS ;
Van De Putte, LBA ;
Lipsky, PE .
FASEB JOURNAL, 1998, 12 (12) :1063-1073
[4]   Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model [J].
Ehrich, EW ;
Dallob, A ;
De Lepeleire, I ;
Van Hecken, A ;
Riendeau, D ;
Yuan, WY ;
Porras, A ;
Wittreich, J ;
Seibold, JR ;
De Schepper, P ;
Mehlisch, DR ;
Gertz, BJ .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1999, 65 (03) :336-347
[5]   TREATMENT OF COLONIC AND RECTAL ADENOMAS WITH SULINDAC IN FAMILIAL ADENOMATOUS POLYPOSIS [J].
GIARDIELLO, FM ;
HAMILTON, SR ;
KRUSH, AJ ;
PIANTADOSI, S ;
HYLIND, LM ;
CELANO, P ;
BOOKER, SV ;
ROBINSON, CR ;
OFFERHAUS, GJA .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (18) :1313-1316
[6]   ASPIRIN AND THE RISK OF COLORECTAL-CANCER IN WOMEN [J].
GIOVANNUCCI, E ;
EGAN, KM ;
HUNTER, DJ ;
STAMPFER, MJ ;
COLDITZ, GA ;
WILLETT, WC ;
SPEIZER, FE .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (10) :609-614
[7]  
LECOMTE M, 1994, J BIOL CHEM, V269, P13207
[8]   Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer [J].
Levy, GN .
FASEB JOURNAL, 1997, 11 (04) :234-247
[9]   Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2 [J].
McAdam, BF ;
Catella-Lawson, F ;
Mardini, IA ;
Kapoor, S ;
Lawson, JA ;
FitzGerald, GA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :272-277
[10]   Suppression of intestinal polyposis in Apc(Delta 716) knockout mice by inhibition of cyclooxygenase 2 (COX-2) [J].
Oshima, M ;
Dinchuk, JE ;
Kargman, SL ;
Oshima, H ;
Hancock, B ;
Kwong, E ;
Trzaskos, JM ;
Evans, JF ;
Taketo, MM .
CELL, 1996, 87 (05) :803-809
1234