Immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants

被引：20

作者：

Almeida, Volia De Carvalho ^{[1
]}

Mussi-Pinhata, Marisa Marcia ^{[2
]}

Sandoval De Souza, Cleonice Barbosa ^{[2
]}

Kubo, Christina Arslanian ^{[3
]}

Martinez, Edson Zangiacomi ^{[4
]}

Carneiro-Sampaio, Magda Maria ^{[5
]}

Duarte, Geraldo ^{[6
]}

机构：

[1] Univ Fed Sao Carlos, Biol & Hlth Sci Ctr, Dept Med, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil

[4] Univ Sao Paulo, Dept Social Med, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[5] Univ Sao Paulo, Dept Pediat, Fac Med, BR-05403900 Sao Paulo, Brazil

[6] Univ Sao Paulo, Dept Gynecol & Obstet, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

VACCINE | 2009年 / 27卷 / 29期

基金：

巴西圣保罗研究基金会;

关键词：

Pneumococcal polysaccharide vaccine; HIV-infected pregnant woman; Passively acquired pneumococcal antibodies; MATERNAL IMMUNIZATION; STREPTOCOCCUS-PNEUMONIAE; PLACENTAL-TRANSFER; 22F POLYSACCHARIDE; CONJUGATE VACCINE; VIRAL LOAD; SERUM IGG; DISEASE; ADULTS; TRANSMISSION;

D O I：

10.1016/j.vaccine.2009.04.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whether gestational immunization of HIV-infected mothers with the 23-valent pneumococcal polysaccharide vaccine (PPV) confers maternal and infant early life, passive protection is not known. We evaluated safety, immunogenicity and placental transfer of antibodies in 44 HIV-infected women. Pneumococcal IgG antibodies against serotypes 1, 3, 5, 613, 9V, and 14 were measured in mothers (pre-vaccination and at delivery), and infants (at birth, 1, 2, 3, and 6 months). PPV was safe and immunogenic in mothers. Newborns received 46-72% of maternal antibody titers. Overall, infants had antibody levels lower than protective by 2 months of age. Alternative pneumococcal vaccination of HIV-infected pregnant women should be explored with the aim of prolonging passive protection in their infants. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3856 / 3861

页数：6

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