Immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants

被引：20

作者：

Almeida, Volia De Carvalho ^{[1
]}

Mussi-Pinhata, Marisa Marcia ^{[2
]}

Sandoval De Souza, Cleonice Barbosa ^{[2
]}

Kubo, Christina Arslanian ^{[3
]}

Martinez, Edson Zangiacomi ^{[4
]}

Carneiro-Sampaio, Magda Maria ^{[5
]}

Duarte, Geraldo ^{[6
]}

机构：

[1] Univ Fed Sao Carlos, Biol & Hlth Sci Ctr, Dept Med, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil

[4] Univ Sao Paulo, Dept Social Med, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[5] Univ Sao Paulo, Dept Pediat, Fac Med, BR-05403900 Sao Paulo, Brazil

[6] Univ Sao Paulo, Dept Gynecol & Obstet, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

VACCINE | 2009年 / 27卷 / 29期

基金：

巴西圣保罗研究基金会;

关键词：

Pneumococcal polysaccharide vaccine; HIV-infected pregnant woman; Passively acquired pneumococcal antibodies; MATERNAL IMMUNIZATION; STREPTOCOCCUS-PNEUMONIAE; PLACENTAL-TRANSFER; 22F POLYSACCHARIDE; CONJUGATE VACCINE; VIRAL LOAD; SERUM IGG; DISEASE; ADULTS; TRANSMISSION;

D O I：

10.1016/j.vaccine.2009.04.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whether gestational immunization of HIV-infected mothers with the 23-valent pneumococcal polysaccharide vaccine (PPV) confers maternal and infant early life, passive protection is not known. We evaluated safety, immunogenicity and placental transfer of antibodies in 44 HIV-infected women. Pneumococcal IgG antibodies against serotypes 1, 3, 5, 613, 9V, and 14 were measured in mothers (pre-vaccination and at delivery), and infants (at birth, 1, 2, 3, and 6 months). PPV was safe and immunogenic in mothers. Newborns received 46-72% of maternal antibody titers. Overall, infants had antibody levels lower than protective by 2 months of age. Alternative pneumococcal vaccination of HIV-infected pregnant women should be explored with the aim of prolonging passive protection in their infants. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3856 / 3861

页数：6

共 50 条

[1]

Abramson JS, 2000, PEDIATRICS, V106, P367, DOI 10.1542/peds.106.2.367

[2] Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: Results from a randomized trial [J].

Ahmed, F ;

Steinhoff, MC ;

RodriguezBarradas, MC ;

Hamilton, RG ;

Musher, DM ;

Nelson, KE .

JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01) :83-90

[3] Safety and immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-1 infected former drug users [J].

Amendola, A ;

Tanzi, E ;

Zappa, A ;

Colzani, D ;

Boschini, A ;

Musher, DM ;

Zanetti, AR .

VACCINE, 2002, 20 (31-32) :3720-3724

[4] Natural materno-fetal transfer of antibodies to PspA and to PsaA [J].

Baril, L ;

Briles, DE ;

Crozier, P ;

King, JD ;

Hollingshead, SK ;

Murphy, TF ;

McCormick, JB .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 135 (03) :474-477

[5] Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children [J].

Black, S ;

Shinefield, H ;

Fireman, B ;

Lewis, E ;

Ray, P ;

Hansen, JR ;

Elvin, L ;

Ensor, KM ;

Hackell, J ;

Siber, G ;

Malinoski, F ;

Madore, D ;

Chang, I ;

Kohberger, R ;

Watson, W ;

Austrian, R ;

Edwards, K .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (03) :187-195

[6] Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine [J].

Brichacek, B ;

Swindells, S ;

Janoff, EN ;

Pirruccello, S ;

Stevenson, M .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (06) :1191-1199

[7]

Brown H, 2015, APPL MIXED MODELS ME

[8] INDUCED GRAVITY-ANOMALIES AND ROCK-BURST RISK IN COAL-MINES - A CASE-HISTORY [J].

CASTEN, U ;

FAJKLEWICZ, Z .

GEOPHYSICAL PROSPECTING, 1993, 41 (01) :1-13

[9] Pneumococcal type 22F polysaccharide absorption improves the specificity of a pneumococcal-polysaccharide enzyme-linked immunosorbent assay [J].

Concepcion, NF ;

Frasch, CE .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2001, 8 (02) :266-272

[10] Human serum β2-microglobulin levels:: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individuals [J].

de Moraes-Pinto, MI ;

Farhat, CK ;

Fraser, WD ;

Hart, CA ;

Johnson, PM .

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1999, 42 (02) :167-174

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