Immunological aspects of circulating DNA

被引：5

作者：

Anker, Philippe ^{[1
]}

Stroun, Maurice ^{[1
]}

机构：

[1] OncoXL, CH-1228 Geneva, Switzerland

来源：

CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM IV | 2006年 / 1075卷

关键词：

lymphocytes; antibodies; DNA;

D O I：

10.1196/annals.1368.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nude mice were injected with DNA released by T lymphocytes previously exposed to inactivated herpes symplex type I or polio viruses. The serum of these mice was tested for its neutralizing activity. Injected nude mice synthesized antiherpetic or antipolio antibodies, depending on the antigen used to sensitize the T lymphocytes. Mice injected with DNA released by human T cells produced antibodies carrying human allotypes as they could be neutralized by antiallotype sera. However, mice that were injected with DNA released by antigen-stimulated murine T lymphocytes produced antiviral antibodies, which were not neutralized by anti-human allotype sera.

引用

页码：34 / 39

页数：6

共 8 条

[1]

ANKER P, 1975, CANCER RES, V35, P2375

[2] NUDE-MICE INJECTED WITH DNA RELEASED BY ANTIGEN STIMULATED HUMAN LYMPHOCYTES-T PRODUCE SPECIFIC ANTIBODIES EXPRESSING HUMAN CHARACTERISTICS [J].