Relationship Between Hematological Parameters and Clinic of Patients Diagnosed as IgA Vasculitis

INTRODUCTION: IgA vasculitis is the most common vasculitis during childhood and gastrointestinal system involvement and renal involvement effect disease course. So we aim to evaluate the relationship between hematological parameters and clinic of patients diagnosed as IgA vasculitis. MATERIALS and METHODS: Study population included the children diagnosed as Ig A vasculitis in Pediatric Nephrology outpatient clinic. We recorded demographic information, clinical findings, laboratory results and ultrasonography results. Leucocyte count, thrombocyte count, mean platelet count (MPV), red cell distribution width (RDW), total neutrophil count, total lymphocyte count, sedimentation, Creactive protein (CRP), hematuria and/or proteinuria, renal function tests and ultrasonography results were recorded. Ratio of neutrophil and lymphocyte was calculated. RESULTS: Of patients 73% had joint involvement, 52% had organ involvement, 35% had gastrointestinal system involvement, 20% had renal involvement. Mean neutrophil count and ration of neutrophil/lymphocyte were higher in patients with organ involvement than without organ involvement. Mean neutrophil count, RDW and CRP levels were higher in patients with renal involvement than without renal renal involvement. As a result hematological parameters at admission may predict oragan, gastrointestinal system and renal involvement. Especially higher neutophil and neutrophil/lymphocyte ratio in patients with organ, gastrointetinal system and renal involvement and higher RDW and CRP levels in patients with renal involvement were significant. Male sex and RDW levels were risk factors for renal involvement. CONCLUSIONS: Hematological parameters at admission may predict the cases with organ, gastrointestinal system and renal involvement. Especially higher ratio of neutrophil/lymphocyte in cases with organ, gastrointestinal system and renal involvement support the role of neutrophils in disease pathogenesis. Male sex and higher RDW levels were risk factors for renal involvement.