Effects of halothane and isoflurane on the contraction, relaxation and energetics of rat diaphragmatic muscle

被引:18
作者
Bouhemad, B
Langeron, O
Orliaguet, G
Coriat, P
Riou, B
机构
[1] Univ Paris 06, Assitance Publ Hop Paris, CHU Pitie Salpetriere,Lab Expt Anaesthesiol, Dept Anaesthesiol & Crit Care, Paris, France
[2] Univ Paris 06, APHP, CHU Necker Enfants Malad, Dept Anaesthesiol & Crit Care, Paris, France
[3] Univ Paris 06, APHP, CHU Pitie Salpetriere, Dept Emergency Med & Surg, Paris, France
关键词
anaesthetics volatile; halothane; isoflurane; muscle skeletal; diaphragm; contractility;
D O I
10.1093/bja/aef204
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background. The inotropic effects of halogenated anaesthetics on diaphragmatic muscle remain a matter of debate. Their effects on its relaxation are poorly understood, although diaphragmatic relaxation is recognized as an important physiological process that may interfere with diaphragmatic performance, fatigue and arterial blood flow. Methods. The effects of halothane and isoflurane (1 or 2x minimum alveolar concentration [1 or 2 MAC]) on contraction and relaxation of rat diaphragm muscle strips (n=40) were studied in vitro from force-velocity curves obtained at various loads from isotonic to isometric conditions. From these curves we determined the peak power output and the curvature. Data are mean (sd) percentage of baseline values. Results. At 1 MAC, isoflurane and halothane induced no significant inotropic and lusitropic effects. At 2 MAC, isoflurane induced a negative inotropic effect (active force, 93(5)% of baseline). Halothane and isoflurane induced a significant decrease in the peak power output at 2 MAC (88(8) and 86(9)% of baseline; P<0.05), without significant changes in the curvature of the force-velocity curve. At 2 MAC isoflurane under high loads and halothane under low loads induced moderate negative lusitropic effects. Conclusion. Halothane and isoflurane induced very moderate inotropic and lusitropic effects, suggesting that the decrease in diaphragm function observed in vivo is not related to a direct effect on diaphragmatic contractility.
引用
收藏
页码:479 / 485
页数:7
相关论文
共 31 条
[11]   DOES HALOTHANE REALLY REDUCE DIAPHRAGMATIC CONTRACTILITY [J].
DRUMMOND, GB .
ANESTHESIOLOGY, 1986, 65 (06) :701-701
[12]   DIFFERENT EFFECTS OF HALOTHANE ON DIAPHRAGM AND HINDLIMB MUSCLE IN RATS [J].
DUREUIL, B ;
VIIRES, N ;
NIVOCHE, Y ;
FIKS, M ;
PARIENTE, R ;
AUBIER, M ;
DESMONTS, JM .
JOURNAL OF APPLIED PHYSIOLOGY, 1987, 63 (05) :1757-1762
[13]   EFFICIENCY OF MECHANICAL POWER DEVELOPMENT DURING MUSCULAR SHORTENING + ITS RELATION TO LOAD [J].
HILL, AV .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 159 (975) :319-+
[14]   NEGATIVE INOTROPY OF HALOGENATED ANESTHETICS IN FERRET VENTRICULAR MYOCARDIUM [J].
HOUSMANS, PR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03) :H827-H834
[15]   Regulation of ventilatory muscle blood flow [J].
Hussain, SNA .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (04) :1455-1468
[16]   MUSCLE STRUCTURE AND THEORIES OF CONTRACTION [J].
HUXLEY, AF .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1957, 7 :255-&
[17]  
IDE T, 1992, ANESTH ANALG, V74, P739
[18]   THE MECHANICAL PROPERTIES OF RELAXING MUSCLE [J].
JEWELL, BR ;
WILKIE, DR .
JOURNAL OF PHYSIOLOGY-LONDON, 1960, 152 (01) :30-47
[19]   The effect of halothane and sevoflurane on fatigue-induced changes in hamster diaphragmatic contractility [J].
Kagawa, T ;
Maekawa, N ;
Mikawa, K ;
Nishina, K ;
Yaku, H ;
Obara, H .
ANESTHESIA AND ANALGESIA, 1998, 86 (02) :392-397
[20]  
KOCHI T, 1990, ANESTH ANALG, V70, P362