Roles of lncRNAs and circRNAs in regulating skeletal muscle development

被引：46

作者：

Chen, Rui ^{[1
]}

Lei, Si ^{[1
]}

Jiang, Ting ^{[2
]}

Zeng, Jie ^{[3
]}

Zhou, Shanyao ^{[1
]}

She, Yanling ^{[1
]}

机构：

[1] Guangdong Second Prov Gen Hosp, Guangdong Tradit Med & Sports Injury Rehabil Res, 466 Xin Gang Zhong Rd, Guangzhou 510317, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Radiol, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Ultrason, Guangzhou, Guangdong, Peoples R China

来源：

ACTA PHYSIOLOGICA | 2020年 / 228卷 / 02期

基金：

中国国家自然科学基金;

关键词：

circRNAs; development; differentiation; lncRNAs; proliferation; skeletal muscle; LONG-NONCODING RNA; ENHANCES MYOGENIC DIFFERENTIATION; DUCHENNE MUSCULAR-DYSTROPHY; CIRCULAR RNA; CELL-PROLIFERATION; PROMOTES DIFFERENTIATION; PROGENITOR CELLS; POOR-PROGNOSIS; MYOBLASTS; MALAT1;

D O I：

10.1111/apha.13356

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The multistep biological process of myogenesis is regulated by a variety of myoblast regulators, such as myogenic differentiation antigen, myogenin, myogenic regulatory factor, myocyte enhancer factor2A-D and myosin heavy chain. Proliferation and differentiation during skeletal muscle myogenesis contribute to the physiological function of muscles. Certain non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in the regulation of muscle development, and the aberrant expressions of lncRNAs and circRNAs are associated with muscular diseases. In this review, we summarize the recent advances concerning the roles of lncRNAs and circRNAs in regulating the developmental aspects of myogenesis. These findings have remarkably broadened our understanding of the gene regulation mechanisms governing muscle proliferation and differentiation, which makes it more feasible to design novel preventive, diagnostic and therapeutic strategies for muscle disorders.

引用

页数：13

共 111 条

[71] STRUCTURE OF THE ACTIN-MYOSIN COMPLEX AND ITS IMPLICATIONS FOR MUSCLE-CONTRACTION [J].