Senescence Evasion in Chemotherapy: A Sweet Spot for p21

被引：10

作者：

Ashraf, Humza M. ^{[1
,2
]}

Moser, Justin ^{[1
,2
]}

Spencer, Sabrina L. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Biochem, Boulder, CO 80309 USA

[2] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA

来源：

CELL | 2019年 / 178卷 / 02期

关键词：

CELLS;

D O I：

10.1016/j.cell.2019.06.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.

引用

页码：267 / 269

页数：4

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