Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease

被引：15

作者：

Al-U'datt, Doa'a G. F. ^{[1
]}

Allen, Bruce G. ^{[2
,3
,4
,5
]}

Hiram, Roddy ^{[3
]}

Alrabadi, Nasr ^{[6
]}

机构：

[1] Jordan Univ Sci & Technol, Fac Med, Dept Physiol & Biochem, Irbid 22110, Jordan

[2] Univ Montreal, Dept Physiol & Pharmacol, Montreal, PQ, Canada

[3] Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada

[4] Univ Montreal, Dept Med, Montreal, PQ, Canada

[5] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada

[6] Jordan Univ Sci & Technol, Dept Pharmacol, Fac Med, Irbid 22110, Jordan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2021年 / 891卷

关键词：

Peptidylarginine deiminases; PADs; Citrullination; Cardiovascular diseases; Myocardial infarction; Heart failure; Fibrosis; Atherosclerosis; Thrombosis; NEUTROPHIL EXTRACELLULAR TRAPS; PROTEIN ARGININE DEIMINASES; DEEP-VEIN THROMBOSIS; CHROMATIN DECONDENSATION; HISTONE DEIMINATION; CITRULLINATION; INHIBITION; MOUSE; ATHEROSCLEROSIS; INVOLVEMENT;

D O I：

10.1016/j.ejphar.2020.173765

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peptidylarginine deiminase (PAD) family members have a vital role in maintaining the stability of the extracellular matrix (ECM) during remodelling in several heart diseases. PAD-mediated deamination, or citrullination, has been studied in different physiological and pathological conditions in the body. However, the role of PAD isoforms has not been fully studied in cardiovascular system. Citrullination is a post-translational modification that involves conversion of peptidyl-based arginine to peptidyl-based citrulline by PAD family members in a calcium-dependent manner. Upregulation of PADs have been observed in various cardiovascular diseases, including venous thrombosis, cardiac fibrosis, heart failure, atherosclerosis, coronary heart disease and acute inflammation. In this review, experimental aspects of in vivo and in vitro studies related to the roles PAD isoforms in cardiovascular diseases including mechanisms, pathophysiological and therapeutic properties are discussed. Pharmacological strategies for targeting PAD family proteins in cardiac diseases have not yet been studied. Furthermore, the role played by PAD family members in the remodelling process during the progression of cardiovascular diseases is not fully understood.

引用

页数：8

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