Intensive Care Unit-Acquired Weakness: Not Just Another Muscle Atrophying Condition

被引:80
作者
Lad, Heta [1 ,2 ]
Saumur, Tyler M. [3 ]
Herridge, Margaret S. [4 ]
dos Santos, Claudia C. [5 ,6 ]
Mathur, Sunita [7 ]
Batt, Jane [5 ,6 ]
Gilbert, Penney M. [1 ,2 ,8 ]
机构
[1] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
[3] Univ Toronto, Rehabil Sci Inst, Toronto, ON M5G 2A2, Canada
[4] Univ Hlth Network, Div Crit Care Med, Toronto, ON M5G 2C4, Canada
[5] St Michaels Unity Hlth Toronto, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1T8, Canada
[6] Univ Toronto, Dept Med, Toronto, ON M5S 3H2, Canada
[7] Univ Toronto, Dept Phys Therapy, Toronto, ON M5G 1V7, Canada
[8] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
muscle atrophy; critical illness; intensive care unit-acquired weakness; critical illness myopathy; critical illness polyneuropathy; COVID-19; SARS-CoV-2; biomarkers; CRITICALLY-ILL PATIENTS; HUMAN SKELETAL-MUSCLE; CRITICAL ILLNESS MYOPATHY; MECHANICALLY VENTILATED PATIENTS; ACTIVATED PROTEIN-KINASE; KAPPA-B ACTIVATION; BED-REST; PROTEOLYTIC ACTIVITY; INDUCED-INHIBITION; ENTERAL NUTRITION;
D O I
10.3390/ijms21217840
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from the critical illness itself, and results in sustained disability long after the ICU stay. Weakness can be attributed to muscle wasting, impaired contractility, neuropathy, and major pathways associated with muscle protein degradation such as the ubiquitin proteasome system and dysregulated autophagy. Furthermore, it is characterized by the preferential loss of myosin, a distinct feature of the condition. While many risk factors for ICUAW have been identified, effective interventions to offset these changes remain elusive. In addition, our understanding of the mechanisms underlying the long-term, sustained weakness observed in a subset of patients after discharge is minimal. Herein, we discuss the various proposed pathways involved in the pathophysiology of ICUAW, with a focus on the mechanisms underpinning skeletal muscle wasting and impaired contractility, and the animal models used to study them. Furthermore, we will explore the contributions of inflammation, steroid use, and paralysis to the development of ICUAW and how it pertains to those with the corona virus disease of 2019 (COVID-19). We then elaborate on interventions tested as a means to offset these decrements in muscle function that occur as a result of critical illness, and we propose new strategies to explore the molecular mechanisms of ICUAW, including serum-related biomarkers and 3D human skeletal muscle culture models.
引用
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页码:1 / 30
页数:30
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共 227 条
  • [61] Carotid and aortic baroreflexes of the rat: I. Open-loop steady-state properties and blood pressure variability
    Dworkin, BR
    Dworkin, S
    Tang, XR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (05) : R1910 - R1921
  • [62] The GH/IGF-1 system in critical illness
    Elijah, Itoro E.
    Branski, Ludwik K.
    Finnerty, Celeste C.
    Herndon, David N.
    [J]. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 25 (05) : 759 - 767
  • [63] GDF15 and Growth Control
    Emmerson, Paul J.
    Duffin, Kevin L.
    Chintharlapalli, Sudhakar
    Wu, Xinle
    [J]. FRONTIERS IN PHYSIOLOGY, 2018, 9
  • [64] Engineering myocardial tissue
    Eschenhagen, T
    Zimmermann, WH
    [J]. CIRCULATION RESEARCH, 2005, 97 (12) : 1220 - 1231
  • [65] An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit-acquired Weakness in Adults
    Fan, Eddy
    Cheek, Fern
    Chian, Linda
    Gosselink, Rik
    Hart, Nicholas
    Herridge, Margaret S.
    Hopkins, Ramona O.
    Hough, Catherine L.
    Kress, John P.
    Latronico, Nicola
    Moss, Marc
    Needham, Dale M.
    Rich, Mark M.
    Stevens, Robert D.
    Wilson, Kevin C.
    Winkelman, Chris
    Zochodne, Doug W.
    Ali, Naeem A.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (12) : 1437 - 1446
  • [66] Physical Complications in Acute Lung Injury Survivors: A Two-Year Longitudinal Prospective Study
    Fan, Eddy
    Dowdy, David W.
    Colantuoni, Elizabeth
    Mendez-Tellez, Pedro A.
    Sevransky, Jonathan E.
    Shanholtz, Carl
    Himmelfarb, Cheryl R. Dennison
    Desai, Sanjay V.
    Ciesla, Nancy
    Herridge, Margaret S.
    Pronovost, Peter J.
    Needham, Dale M.
    [J]. CRITICAL CARE MEDICINE, 2014, 42 (04) : 849 - 859
  • [67] Protein Requirements in the Critically Ill: A Randomized Controlled Trial Using Parenteral Nutrition
    Ferrie, Suzie
    Allman-Farinelli, Margaret
    Daley, Mark
    Smith, Kristine
    [J]. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2016, 40 (06) : 795 - 805
  • [68] Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study
    Finfer, Simon
    [J]. INTENSIVE CARE MEDICINE, 2015, 41 (06) : 1037 - 1047
  • [69] The role of hormones in muscle hypertrophy
    Fink, Julius
    Schoenfeld, Brad Jon
    Nakazato, Koichi
    [J]. PHYSICIAN AND SPORTSMEDICINE, 2018, 46 (01) : 129 - 134
  • [70] Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness
    Fletcher, SN
    Kennedy, DD
    Ghosh, IR
    Misra, VP
    Kiff, K
    Coakley, JH
    Hinds, CJ
    [J]. CRITICAL CARE MEDICINE, 2003, 31 (04) : 1012 - 1016