An N-heterocyclic carbene-catalyzed [8+3] annulation of tropone and enals via homoenolate

被引：87

作者：

Nair, Vijay ^{[1
]}

Poonoth, Manojkumar

Vellalath, Sreekumar

Suresh, Eringathodi

Thirumalai, Rajasekaran

机构：

[1] CSIR, Reg Res Lab, Organ Chem Sect, Trivandrum 695019, Kerala, India

[2] CSIR, Cent Salt & Marine Chem Inst, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 23期

关键词：

D O I：

10.1021/jo0615706

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel protocol for the annulation of tropone to enals involving nucleophilic heterocyclic carbene (NHC) catalyzed homoenolate formation has been developed. Interestingly, the reaction led to bicyclic delta-lactones instead of the expected gamma-spirolactones, presumably by the uncommon [8 + 3] annulation pathway. The strategy works well with a variety of enals.

引用

页码：8964 / 8965

页数：2

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