The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients

被引：45

作者：

Abra, RM ^{[1
]}

Bankert, RB

Chen, F

Egilmez, NK

Huang, K

Saville, R

Slater, JL

Sugano, M

Yokota, SJ

机构：

[1] ALZA Corp, Mt View, CA 94025 USA

[2] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

来源：

JOURNAL OF LIPOSOME RESEARCH | 2002年 / 12卷 / 1-2期

关键词：

D O I：

10.1081/LPR-120004770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-beta(1) integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-tabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

引用

页码：1 / 3

页数：3