Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate

被引：1

作者：

Guan Ruqi ^{[1
]}

Chao Guoku ^{[1
]}

Ye Caiping ^{[1
]}

Wang Yuxiang ^{[1
]}

Liu Yanmei ^{[1
]}

Li Haihua ^{[1
]}

Zhao Yajuan ^{[1
]}

Tai Yulei ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2014年 / 30卷 / 02期

关键词：

Selective hydrogenation; Supported amorphous catalyst; Ru-B/gamma-Al2O3; Indole derivative; ALLOY CATALYST; INDOLES; RU;

D O I：

10.1007/s40242-014-3421-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ru-B/gamma-Al2O3 catalyst was prepared by reductant impregnation method, which was applied in the selective hydrogenation of ethyl 1H-indole-2-carboxylate for producing ethyl 2,3,3a, 7a-tetrahydro-1H-indole-2-carboxylate with hydrogen as reductant. Furthermore, we discussed the influences of substrate concentration, reaction solvent, hydrogenation temperature, initial hydrogen pressure and reaction time on the catalytic performance of the as-prepared catalyst. The obtained Ru-B/gamma-Al2O3 catalyst showed a high-efficiency for the selective hydrogenation of ethyl 1H-indole-2-carboxylate(>99% conversion and selectivity) in i-propanol used as solvent at a concentration of 10%(mass fraction) of ethyl 1H-indole-2-carboxylate, a pressure of hydrogen of 6 MPa and a reaction temperature of 373 K.

引用

页码：284 / 288

页数：5

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