Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization

被引：47

作者：

Das, Biswarup ^{[1
]}

Dutta, Sukrit ^{[1
]}

Nayak, Amit Kumar ^{[1
]}

Nanda, Upendranath ^{[1
]}

机构：

[1] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Orissa, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 70卷

关键词：

Sodium alginate; Carboxymethyl cashew gum; Isoxsuprine HCl; TAMARIND SEED POLYSACCHARIDE; MUCOADHESIVE BEADS; IN-VITRO; FORMULATION; DELIVERY; DESIGN;

D O I：

10.1016/j.ijbiomac.2014.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isoxsuprine HCl-loaded microbeads using sodium alginate (SA)-carboxymethyl cashew gum (CMCG) polymer-blends were developed through ionotropic-gelation technique using ZnSO4 as cross-linker. Effects of polymer-blend ratio and cross-linker concentration on drug encapsulation efficiency (DEE) and cumulative drug release at 7 h (R-7h) were optimized by 3(2) factorial design. Optimized microbeads were of excellent combination of high DEE (79.92 +/- 2.51%) and suitable sustained drug release pattern over a prolonged period of 7 h (58.67 +/- 2.26%). The microbead surface morphology was analyzed by SEM. The physical state of isoxsuprine HCl within the optimized microbead matrix was analyzed by FTIR and DSC. In vitro isoxsuprine HCl release from alginate-CMCG microbeads in phosphate buffer (pH, 6.8) showed prolonged sustained drug release and Korsmeyer-Peppas model (R-2 = 0.9959-0.9992) over 7 h. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：506 / 515

页数：10

共 40 条

[1] Application of response surface methodology to formulation of ionotropically gelled gum cordia/gellan beads [J].

Ahuja, Munish ;

Yadav, Monika ;

Kumar, Sumit .

CARBOHYDRATE POLYMERS, 2010, 80 (01) :161-167

[2]

Banerjee S, 2010, J SCI IND RES INDIA, V69, P777

[3] Cross-linked guar gum microspheres: A viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer [J].

Chaurasia, Mohini ;

Chourasia, Manish K. ;

Jain, Nitin K. ;

Jain, Aviral ;

Soni, Vandana ;

Gupta, Yashwant ;

Jain, Sanjay K. .

AAPS PHARMSCITECH, 2006, 7 (03)

[4] Topical gels of lidocaine HCl using cashew gum and Carbopol 940: Preparation and in vitro skin permeation [J].

Das, Biswarup ;

Nayak, Amit Kumar ;

Nanda, Upendranath .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 62 :514-517

[5] COMPOSITION AND RHEOLOGICAL PROPERTIES OF CASHEW TREE GUM, THE EXUDATE POLYSACCHARIDE FROM ANACARDIUM-OCCIDENTALE L [J].

DEPAULA, RCM ;

RODRIGUES, JF .

CARBOHYDRATE POLYMERS, 1995, 26 (03) :177-181

[6] Gastrointestinal delivery of glipizide from carboxymethyl locust bean gumAl3+alginate hydrogel network: In vitro and in vivo performance [J].

Dey, Paramita ;

Maiti, Sabyasachi ;

Sa, Biswanath .

JOURNAL OF APPLIED POLYMER SCIENCE, 2013, 128 (03) :2063-2072

[7] Alginates as a useful natural polymer for microencapsulation and therapeutic applications [J].

Goh, Cheong Hian ;

Heng, Paul Wan Sia ;

Chan, Lai Wah .

CARBOHYDRATE POLYMERS, 2012, 88 (01) :1-12

[8] Development of buccal tablets for curcumin using Anacardium occidentale gum [J].

Gowthamarajan, K. ;

Jawahar, N. ;

Wake, Prashant ;

Jain, Kunal ;

Sood, Sumeet .

CARBOHYDRATE POLYMERS, 2012, 88 (04) :1177-1183

[9] Preliminary study of Anacardium occidentale gum as binder in formulation of paracetamol tablets [J].

Gowthamarajan, K. ;

Kumar, G. Kanaka Phani ;

Gaikwad, Narayan Babulal ;

Suresh, B. .

CARBOHYDRATE POLYMERS, 2011, 83 (02) :506-511

[10] Aceclofenac-loaded unsaturated esterified alginate/gellan gum microspheres: In vitro and in vivo assessment [J].

Jana, Sougata ;

Das, Arindam ;

Nayak, Amit Kumar ;

Sen, Kalyan Kumar ;

Basu, Sanat Kumar .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 57 :129-137

← 1 2 3 4 →