Thiamin nutrition and catalysis-induced instability of thiamin diphosphate

被引：27
作者：
McCourt, Jennifer A. [1 ]
Nixon, Peter F. [1 ]
Duggleby, Ronald G. [1 ]
机构：
[1] Univ Queensland, Sch Mol & Microbiol Sci, Brisbane, Qld 4072, Australia
来源：
BRITISH JOURNAL OF NUTRITION | 2006年 / 96卷 / 04期
基金：
澳大利亚研究理事会;
关键词：
cofactor instability; dietary requirement; energy metabolism; enzyme cofactor; thiamin diphosphate; vitamin B-1;
D O I：
10.1079/BJN20061842
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Thiamin (vitamin B1) is required in animal diets because it is the precursor of the enzyme cofactor, thiamin diphosphate. Unlike other B vitamins, the dietary thiamin requirement is proportional to non-fat energy intake but there is no obvious biochemical reason for this relationship. In the present communication we show for two enzymes that the cofactor undergoes a slow destruction during catalysis, which may explain the interdependence of thiamin and energy intakes.
引用
收藏
页码：636 / 638
页数：3
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