Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats-An in vivo approach

被引：83

作者：

Karthick, V. ^{[1
]}

Kumar, V. Ganesh ^{[1
]}

Dhas, T. Stalin ^{[1
]}

Singaravelu, G. ^{[3
]}

Sadiq, A. Mohamed ^{[2
]}

Govindaraju, K. ^{[1
]}

机构：

[1] Sathyabama Univ, Ctr Ocean Res, Nanosci Div, Madras 600119, Tamil Nadu, India

[2] Adhiparasakthi Coll Arts & Sci, Dept Biochem, Kalavai 632506, India

[3] Thiruvalluvar Univ, Dept Zool, Nanosci Div, Vellore 632115, Tamil Nadu, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 122卷

关键词：

Diabetes; Gold nanoparticles; Gymnema sylvestre; Electron microscopy; Hypoglycemia; GYMNEMA-SYLVESTRE; LEAF EXTRACT; GLYCOSYLATED HEMOGLOBIN; SILVER NANOPARTICLES; STREPTOZOTOCIN; BIOSYNTHESIS; METABOLISM; MECHANISMS; APOPTOSIS; GLUCOSE;

D O I：

10.1016/j.colsurfb.2014.07.022

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a longtime. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP). (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：505 / 511

页数：7

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