Survival of the Fittest: Competitive Co-crystal Reactions in the Ball Mill

被引：42

作者：

Fischer, Franziska ^{[1
,2
]}

Joester, Maike ^{[1
,2
]}

Rademann, Klaus ^{[2
]}

Emmerling, Franziska ^{[1
]}

机构：

[1] BAM Fed Inst Mat Res & Testing, D-12489 Berlin, Germany

[2] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 42期

关键词：

crystal engineering; kinetics; mechanochemistry; structure determination; X-ray diffraction; PYRIDINE HYDROGEN-BONDS; X-RAY-DIFFRACTION; PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHONS; SOLID-STATE; PHYSICOCHEMICAL PROPERTIES; MECHANOCHEMICAL SYNTHESIS; ORGANIC-COMPOUNDS; CARBOXYLIC-ACIDS; REAL-TIME;

D O I：

10.1002/chem.201500925

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The driving forces triggering the formation of co-crystals under milling conditions were investigated by using a set of multicomponent competitive milling reactions. In these reactions, different active pharmaceutical ingredients were ground together with a further compound acting as coformer. The study was based on new co-crystals including the coformer anthranilic acid. The results of the competitive milling reactions indicate that the formation of co-crystals driven by intermolecular recognition are influenced and inhibited by kinetic aspects including the formation of intermediates and the stability of the reactants.

引用

页码：14969 / 14974

页数：6

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