The long non-coding RNA landscape in triple-negative breast cancer

被引：53

作者：

Zhang, Wenwen ^{[1
]}

Guan, Xiaoxiang ^{[2
]}

Tang, Jinhai ^{[3
]}

机构：

[1] Nanjing Med Univ, Dept Oncol, Nanjing Hosp 1, 68 Changle Rd, Nanjing 210006, Peoples R China

[2] Nanjing Med Univ, Dept Oncol, Affiliated Hosp 1, Nanjing, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, 300 Guangzhou Rd, Nanjing 210029, Peoples R China

来源：

CELL PROLIFERATION | 2021年 / 54卷 / 02期

基金：

中国国家自然科学基金;

关键词：

biomarkers; LncRNA; LncRNA‐ based therapeutics; prognosis; triple‐ negative breast cancer; REGULATES CELL-PROLIFERATION; ANTISENSE OLIGONUCLEOTIDES; MESENCHYMAL TRANSITION; TRANSCRIPTOME ANALYSIS; MOLECULAR PORTRAITS; DNA METHYLATION; NEXT-GENERATION; LNCRNA; INVASION; PROMOTES;

D O I：

10.1111/cpr.12966

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Triple-negative breast cancer (TNBC) is a type of breast cancer that has a higher risk of distant recurrence and metastasis, leading to a relatively aggressive biological behaviour and poor outcome. So far, the clinical management of TNBC is challenging because of its heterogeneity and paucity of specific targeted therapy. Recently, various studies have identified a lot of differently expressed long non-coding RNAs (lncRNAs) in TNBC. Those lncRNAs have been reported to play important roles in the multistep process of TNBC tumorigenesis. Here, we review the biological characteristics of lncRNAs, and present the current state of knowledge concerning the expression, function and regulation of lncRNAs in TNBC. Accumulating studies explored the potential lncRNAs-based therapeutics in TNBC, including the techniques of genetic modification using antisense oligonucleotides, locked nucleic acid and RNA nanotechnology. In current review, we also discuss the future prospects of studies about lncRNAs in TNBC and development of lncRNA-based strategies for clinical TNBC patients.

引用

页数：16

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