Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia

被引：21

作者：

Simon, MC ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

CELL | 2004年 / 117卷 / 07期

关键词：

D O I：

10.1016/j.cell.2004.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O-2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2. This preview examines cellular responses to O-2 deprivation (hypoxia) and the complexity of the regulation of the HIF O-2 sensing pathway in mammals.

引用

页码：851 / 853

页数：3

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