Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats

被引：15

作者：

Ghadermazi, Rozhin ^{[1
]}

Khoshjou, Farhad ^{[2
]}

Zijoud, Seyed Mostafa Hossini ^{[3
]}

Behrooj, Hamid ^{[4
]}

Kheiripour, Nejat ^{[4
]}

Ganji, Maziar ^{[1
]}

Moridi, Heresh ^{[4
]}

Mohammadi, Mojdeh ^{[5
]}

Ranjbar, Akram ^{[5
]}

机构：

[1] Hamadan Univ Med Sci, Student Res Ctr, Hamadan, Iran

[2] Hamadan Univ Med Sci, Urol Res Ctr, Hamadan, Iran

[3] Baqiyatallah Univ Med Sci, Nephrol & Urol Res Ctr, Tehran, Iran

[4] Hamadan Univ Med Sci, Dept Biochem, Fac Med, Hamadan, Iran

[5] Hamadan Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Hamadan, Iran

来源：

TOXIN REVIEWS | 2018年 / 37卷 / 01期

关键词：

Tempol; ALT; AST; oxidative toxic stress; diabetes; LIVER; ANTIOXIDANTS; DISEASE; INJURY;

D O I：

10.1080/15569543.2017.1313277

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Tempol is a synthetic antioxidant. Since many studies revealed the protective effect of antioxidants on liver, current study was performed to assess the hepatoprotective effects of tempol on streptozotocin induced diabetic rats. Blood glucose, oxidative toxic stress (OTS) biomarkers and liver enzymes were measured. Findings showed that tempol significantly decreased serum levels of glucose in tempol treated group. Also treatment with tempol significantly reduced AST and ALT compared to diabetic control group (p<0.05). Finally, tempol decreased the OTS level compared to the diabetic group. It can be concluded that treatment with tempol exhibits hepatoprotective effects in diabetic rats through reduction of OTS.

引用

页码：82 / 86

页数：5

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