Hematopoietic Cell Transplantation for Systemic Sclerosis-A Review

被引：7

作者：

Levin, Daniel ^{[1
]}

Osman, Mohammed S. ^{[2
]}

Durand, Caylib ^{[1
]}

Kim, Hyein ^{[3
]}

Hemmati, Iman ^{[3
]}

Jamani, Kareem ^{[1
]}

Howlett, Jonathan G. ^{[1
]}

Johannson, Kerri A. ^{[1
]}

Weatherald, Jason ^{[1
,2
]}

Woo, Matthew ^{[1
]}

Lee, Jason ^{[1
]}

Storek, Jan ^{[1
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Calgary, AB T2N 4N1, Canada

[2] Univ Alberta, Fac Med, Edmonton, AB T6G 2R7, Canada

[3] Univ British Columbia, Fac Med, Vancouver, BC V6T 1Z3, Canada

来源：

CELLS | 2022年 / 11卷 / 23期

关键词：

systemic sclerosis; hematopoietic stem cell transplant; sclerosis; ILD; TERM-FOLLOW-UP; AUTOIMMUNE-DISEASES; MARROW-TRANSPLANTATION; MULTIPLE-SCLEROSIS; BONE-MARROW; PULSE CYCLOPHOSPHAMIDE; IMMUNE RECONSTITUTION; CONDITIONING REGIMEN; ENGRAFTMENT SYNDROME; PERIPHERAL-BLOOD;

D O I：

10.3390/cells11233912

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy. Autologous hematopoietic stem cell transplantation (HCT) is more efficacious but carries associated risks, including treatment-related mortality. Here, we review HCT as a treatment for SSc, its efficacy and toxicity in comparison to conventional therapies, and the proposed mechanisms of action. Furthermore, we discuss the importance of and recent developments in patient selection. Finally, we highlight the knowledge gaps and future work required to further improve patient outcomes.

引用

页数：26

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