Cardiopulmonary bypass increases plasma bradykinin concentrations

被引：24

作者：

Cugno, M

Nussberger, J

Biglioli, P

Giovagnoni, MG

Gardinali, M

Agostoni, A

机构：

[1] Univ Milan, Dept Internal Med, IRCCS, Maggiore Hosp, I-20122 Milan, Italy

[2] Univ Milan, IRCCS, Div Cardiac Surg, Fdn Monzino, I-20122 Milan, Italy

[3] Univ Lausanne Hosp, Div Hypertens, Lausanne, Switzerland

来源：

IMMUNOPHARMACOLOGY | 1999年 / 43卷 / 2-3期

关键词：

bradykinin; cardiopulmonary bypass; catabolism;

D O I：

10.1016/S0162-3109(99)00072-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：145 / 147

页数：3

共 5 条

[1]

BHOOLA KD, 1992, PHARMACOL REV, V44, P1

[2] ACTIVATION OF THE CONTACT SYSTEM AND FIBRINOLYSIS IN AUTOIMMUNE ACQUIRED ANGIOEDEMA - A RATIONALE FOR PROPHYLACTIC USE OF TRANEXAMIC ACID [J].