Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids

被引：14

作者：

Jeong, Yong-Chul ^{[1
]}

Anwar, Muhammad ^{[1
]}

Moloney, Mark G. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 08期

关键词：

Tetramate; Antibacterial; Enamine; TETRONIC ACIDS; ANTIBACTERIAL; DERIVATIVES; ANTIFUNGAL; DISCOVERY; INHIBITOR; BIOLOGY; POTENT; DOMAIN;

D O I：

10.1016/j.bmcl.2014.03.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and evaluation of 3-enaminetetramic acids as antibacterial agents is reported; contrary to the analogous 3-acyltetramic acids, the enaminetetramic acid class of compound exhibits modest antibacterial activity against a limited spectrum of organisms, and even that activity is strongly dependent on the identity of the tetramate ring substituents. Moreover, these compounds appear to have a different mode of action to the analogous 3-acyltetramic acids, and appear to offer more limited opportunity for further elaboration in drug discovery. Crown Copyright (c) 2014 Published by Elsevier Ltd. All rights reserved.

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页码：1901 / 1906

页数：6

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