Analysis of Plasma Multiplex Cytokines for Children With Febrile Seizures and Severe Acute Encephalitis

被引：20

作者：

Hu, Mei-Hua ^{[1
,2
,3
,4
,5
]}

Huang, Go-Shine ^{[6
]}

Wu, Chang-Teng ^{[3
,4
]}

Lin, Jainn-Jim ^{[4
,5
,7
,8
,9
]}

Hsia, Shao-Hsuan ^{[4
,7
]}

Wang, Huei-Shyong ^{[4
,8
,9
]}

Lin, Kuang-Lin ^{[4
,8
,9
]}

机构：

[1] Chang Gung Mem Hosp, Dept Pediat, Keelung, Taiwan

[2] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan

[3] Chang Gung Univ, Coll Med, Dept Gen Pediat, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Tao Yuan, Taiwan

[5] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Tao Yuan, Taiwan

[6] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Anesthesiol, Taipei, Taiwan

[7] Chang Gung Univ, Coll Med, Div Pediat Crit Care & Emergency Med, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[8] Chang Gung Univ, Coll Med, Dept Pediat Neurol, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[9] Chang Gung Childrens Hosp, Study Grp Children Encephalitis Encephalopathy Re, Tao Yuan, Taiwan

来源：

JOURNAL OF CHILD NEUROLOGY | 2014年 / 29卷 / 02期

关键词：

cytokine; febrile seizures; severe acute encephalitis; interleukin-6; inflammation; TRAUMATIC BRAIN-INJURY; OXIDATIVE STRESS; INTERLEUKIN-6; NEURONS; IL-6;

D O I：

10.1177/0883073813488829

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1, interferon-, and tumor necrosis factor- were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.

引用

页码：182 / 186

页数：5

共 20 条

[11]

Lin JJ, 2012, J CHILD NEUROL

[12] High production of interleukin-10 and interferon-? in influenza-associated MERS in the early phase [J].

Morichi, Shinichiro ;

Kawashima, Hisashi ;

Ioi, Hiroaki ;

Yamanaka, Gaku ;

Kashiwagi, Yasuyo ;

Hoshika, Akinori .

PEDIATRICS INTERNATIONAL, 2012, 54 (04) :536-538

[13] Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures [J].

Penkowa, M ;

Molinero, A ;

Carrasco, J ;

Hidalgo, J .

NEUROSCIENCE, 2001, 102 (04) :805-818

[14] Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices [J].

Pizzi, M ;

Sarnico, I ;

Boroni, F ;

Benarese, M ;

Dreano, M ;

Garotta, G ;

Valerio, A ;

Spano, PF .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 25 (02) :301-311

[15] Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability [J].

Riazi, Kiarash ;

Galic, Michael A. ;

Pittman, Quentin J. .

EPILEPSY RESEARCH, 2010, 89 (01) :34-42

[16] Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress [J].

Shih, AY ;

Johnson, DA ;

Wong, G ;

Kraft, AD ;

Jiang, L ;

Erb, H ;

Johnson, JA ;

Murphy, TH .

JOURNAL OF NEUROSCIENCE, 2003, 23 (08) :3394-3406

[17] Pro- and anti-inflammatory cytokines in children with febrile convulsions [J].

Straussberg, R ;

Amir, J ;

Harel, L ;

Punsky, I ;

Bessler, H .

PEDIATRIC NEUROLOGY, 2001, 24 (01) :49-53

[18] Encephalitis in children [J].

Thompson, Clara ;

Kneen, Rachel ;

Riordan, Andrew ;

Kelly, Dominic ;

Pollard, Andrew J. .

ARCHIVES OF DISEASE IN CHILDHOOD, 2012, 97 (02) :150-161

[19] INTERLEUKIN-6 PROTECTS CULTURED RAT HIPPOCAMPAL-NEURONS AGAINST GLUTAMATE-INDUCED CELL-DEATH [J].

YAMADA, M ;

HATANAKA, H .

BRAIN RESEARCH, 1994, 643 (1-2) :173-180

[20] A meta-analysis of pro-inflammatory cytokines in the plasma of epileptic patients with recent seizure [J].

Yu, Nian ;

Di, Qing ;

Hu, Yong ;

Zhang, Yan-fang ;

Su, Ling-ying ;

Liu, Xin-hong ;

Li, Le-chao .

NEUROSCIENCE LETTERS, 2012, 514 (01) :110-115

← 1 2 →