Analysis of Plasma Multiplex Cytokines for Children With Febrile Seizures and Severe Acute Encephalitis

被引：20

作者：

Hu, Mei-Hua ^{[1
,2
,3
,4
,5
]}

Huang, Go-Shine ^{[6
]}

Wu, Chang-Teng ^{[3
,4
]}

Lin, Jainn-Jim ^{[4
,5
,7
,8
,9
]}

Hsia, Shao-Hsuan ^{[4
,7
]}

Wang, Huei-Shyong ^{[4
,8
,9
]}

Lin, Kuang-Lin ^{[4
,8
,9
]}

机构：

[1] Chang Gung Mem Hosp, Dept Pediat, Keelung, Taiwan

[2] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan

[3] Chang Gung Univ, Coll Med, Dept Gen Pediat, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Tao Yuan, Taiwan

[5] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Tao Yuan, Taiwan

[6] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Anesthesiol, Taipei, Taiwan

[7] Chang Gung Univ, Coll Med, Div Pediat Crit Care & Emergency Med, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[8] Chang Gung Univ, Coll Med, Dept Pediat Neurol, Chang Gung Childrens Hosp, Tao Yuan, Taiwan

[9] Chang Gung Childrens Hosp, Study Grp Children Encephalitis Encephalopathy Re, Tao Yuan, Taiwan

来源：

JOURNAL OF CHILD NEUROLOGY | 2014年 / 29卷 / 02期

关键词：

cytokine; febrile seizures; severe acute encephalitis; interleukin-6; inflammation; TRAUMATIC BRAIN-INJURY; OXIDATIVE STRESS; INTERLEUKIN-6; NEURONS; IL-6;

D O I：

10.1177/0883073813488829

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1, interferon-, and tumor necrosis factor- were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.

引用

页码：182 / 186

页数：5

共 20 条

[1] Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain [J].

Ali, C ;

Nicole, O ;

Docagne, F ;

Lesne, S ;

MacKenzie, ET ;

Nouvelot, A ;

Buisson, A ;

Vivien, D .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (06) :956-966

[2] IL-8 in Cerebrospinal Fluid from Children with Acute Encephalopathy is Higher than in that from Children with Febrile Seizure [J].

Asano, T. ;

Ichiki, K. ;

Koizumi, S. ;

Kaizu, K. ;

Hatori, T. ;

Fujino, O. ;

Mashiko, K. ;

Sakamoto, Y. ;

Miyasho, T. ;

Fukunaga, Y. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 71 (06) :447-451

[3] Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injury [J].

Chiaretti, Antonio ;

Antonelli, Alessia ;

Mastrangelo, Antonio ;

Pezzotti, Patrizio ;

Tortorolo, Luca ;

Tosi, Federica ;

Genovese, Orazio .

JOURNAL OF NEUROTRAUMA, 2008, 25 (03) :225-234

[4] Encephalitis in the Pediatric Population [J].

Falchek, Stephen J. .

PEDIATRICS IN REVIEW, 2012, 33 (03) :122-133

[5] Interleukin-6 attenuates hyperthermia-induced seizures in developing rats [J].

Fukuda, Mitsumasa ;

Morimoto, Takehiko ;

Suzuki, Yuka ;

Shinonaga, Chiya ;

Ishida, Yasushi .

BRAIN & DEVELOPMENT, 2007, 29 (10) :644-648

[6] Cytokines and brain excitability [J].

Galic, Michael A. ;

Riazi, Kiarash ;

Pittman, Quentin J. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2012, 33 (01) :116-125

[7] Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo [J].

Hoang-Yen Phi Tran ;

Shin, Eun-Joo ;

Saito, Kuniaki ;

Xuan-Khanh Thi Nguyen ;

Chung, Yoon Hee ;

Jeong, Ji Hoon ;

Bach, Jae-Hyung ;

Park, Dae Hun ;

Yamada, Kiyofumi ;

Nabeshima, Toshitaka ;

Yoneda, Yukio ;

Kim, Hyoung-Chun .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (07) :1159-1174

[8] Interleukin-10 is associated with resistance to febrile seizures: Genetic association and experimental animal studies [J].

Ishizaki, Yoshito ;

Kira, Ryutaro ;

Fukuda, Mitsumasa ;

Torisu, Hiroyuki ;

Sakai, Yasunari ;

Sanefuji, Masafumi ;

Yukaya, Naoko ;

Hara, Toshiro .

EPILEPSIA, 2009, 50 (04) :761-767

[9] Cytokines and chemokines in viral encephalitis: A clinicoradiological correlation [J].

Kalita, Jayantee ;

Srivastava, Ruchi ;

Mishra, Manoj Kumar ;

Basu, Anirban ;

Misra, Usha Kant .

NEUROSCIENCE LETTERS, 2010, 473 (01) :48-51

[10] IL6 Deficiency Affects Function After Traumatic Brain Injury [J].

Ley, Eric J. ;

Clond, Morgan A. ;

Singer, Matt B. ;

Shouhed, Daniel ;

Salim, Ali .

JOURNAL OF SURGICAL RESEARCH, 2011, 170 (02) :253-256

← 1 2 →