Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4

被引：0

作者：

Kim, Min-Seok ^{[1
]}

Takahashi, Tsutomu ^{[1
]}

Lee, Jin-Yong ^{[1
,2
]}

Hwang, Gi-Wook ^{[1
]}

Naganuma, Akira ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Mol & Biochem Toxicol, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Aichi Gakuin Univ, Sch Pharm, Lab Pharmaceut Hlth Sci, Chikusa Ku, Nagoya, Aichi 4648650, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2013年 / 38卷 / 06期

关键词：

Methylmercury; Chemokine; Induction; Brain; CCL3; CCL4; NF-KAPPA-B; MICROARRAY ANALYSIS; ACTIVATION; ERK;

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We previously reported that methylmercury induces brain-specific upregulation of a chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercury-treated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, in a brain-specific manner. This finding suggests that upregulation of these two chemokine genes mediates selective damage by methylmercury in the central nervous system.

引用

收藏

页码：925 / 929

页数：5

相关论文

共 13 条

[1]

Castoldi Anna F, 2003, Rev Environ Health, V18, P19

[2] G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity [J].

Gamo, Kazushige ;

Kiryu-Seo, Sumiko ;

Konishi, Hiroyuki ;

Aoki, Shunsuke ;

Matsushima, Kouji ;

Wada, Keiji ;

Kiyama, Hiroshi .

JOURNAL OF NEUROSCIENCE, 2008, 28 (46) :11980-11988

[3] Estradiol inhibits ongoing autoimmune neuroinflammation and NFκB-dependent CCL2 expression in reactive astrocytes [J].

Giraud, Sebastien N. ;

Caron, Cecile M. ;

Pham-Dinh, Danielle ;

Kitabgi, Patrick ;

Nicot, Arnaud B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8416-8421

[4] Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy [J].

Gorter, Jan A. ;

van Vliet, Erwin A. ;

Aronica, Eleonora ;

Breit, Timo ;

Rauwerda, Han ;

da Silva, Fernando H. Lopes ;

Wadman, Wytse J. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (43) :11083-11110

[5] Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury [J].

Hwang, Gi-Wook ;

Lee, Jin-Yong ;

Ryoke, Katsunori ;

Matsuyama, Fujio ;

Kim, Jong-Mu ;

Takahashi, Tsutomu ;

Naganuma, Akira .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2011, 36 (03) :389-391

[6] Amyloid-β peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway [J].

Ito, Sachiko ;

Sawada, Makoto ;

Haneda, Masataka ;

Ishida, Yoshiyuki ;

Isobe, Ken-ichi .

NEUROSCIENCE RESEARCH, 2006, 56 (03) :294-299

[7] Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes [J].

Kim, Min-Seok ;

Takahashi, Tsutomu ;

Lee, Jin-Yong ;

Hwang, Gi-Wook ;

Naganuma, Akira .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2012, 37 (06) :1275-1278

[8] Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice [J].

Lee, Jin-Yong ;

Hwang, Gi-Wook ;

Kim, Min-Seok ;

Takahashi, Tsutomu ;

Naganuma, Akira .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2012, 37 (06) :1279-1282

[9]

Murdoch C, 2000, BLOOD, V95, P3032

[10] Analysis of Functional Pathways Altered after Mild Traumatic Brain Injury [J].

Redell, John B. ;

Moore, Anthony N. ;

Grill, Raymond J. ;

Johnson, Daniel ;

Zhao, Jing ;

Liu, Yin ;

Dash, Pramod K. .

JOURNAL OF NEUROTRAUMA, 2013, 30 (09) :752-764