Background: Spinal cord pathology is an important substrate for long-term disability in multiple sclerosis (MS). Objective: To investigate longitudinal changes in spinal cord lesions and atrophy in patients with a non spinal clinically isolated syndrome (CIS), and how they relate to the development of disability. Methods: In all, 131 patients with a non-spinal CIS had brain and spinal cord imaging at the time of CIS and approximately 5 years later (median: 5.2 years, range: 3.0-7.9 years). Brain magnetic resonance imaging (MRI) measures consisted of T2-hyperintense and T1-hypointense lesion loads plus brain atrophy. Spinal cord MRI measures consisted of lesion number and the upper cervical cord cross-sectional area (UCCA). Disability was measured using the Expanded Disability Status Scale (EDSS). Multiple linear regression was used to identify independent predictors of disability after 5 years. Results: During follow-up, 93 (71%) patients were diagnosed with MS. Baseline spinal cord lesion number, change in cord lesion number and change in UCCA were independently associated with EDSS (R-2=0.53) at follow-up. Including brain T2 lesion load and brain atrophy only modestly increased the predictive power of the model (R-2=0.64). Conclusion: Asymptomatic spinal cord lesions and spinal cord atrophy contribute to the development of MS-related disability over the first 5 years after a non-spinal CIS.
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Bonati, U.
Fisniku, L. K.
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机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Fisniku, L. K.
Altmann, D. R.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, England
London Sch Hyg & Trop Med, Med Stat Unit, London WC1, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Altmann, D. R.
Yiannakas, M. C.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Yiannakas, M. C.
Furby, J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Furby, J.
Thompson, A. J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, England
UCL, Dept Brain Repair & Rehabil, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Thompson, A. J.
Miller, D. H.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Miller, D. H.
Chard, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
机构:
Univ Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, EnglandUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Horsfield, Mark A.
Sala, Stefania
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Sala, Stefania
Neema, Mohit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Neema, Mohit
Absinta, Martina
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Absinta, Martina
Bakshi, Anshika
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Bakshi, Anshika
Sormani, Maria Pia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Genoa, Dept Hlth Sci DISSAL, Biostat Unit, Genoa, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Sormani, Maria Pia
Rocca, Maria A.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Rocca, Maria A.
Bakshi, Rohit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Bakshi, Rohit
Filippi, Massimo
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Bonati, U.
Fisniku, L. K.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Fisniku, L. K.
Altmann, D. R.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, England
London Sch Hyg & Trop Med, Med Stat Unit, London WC1, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Altmann, D. R.
Yiannakas, M. C.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Yiannakas, M. C.
Furby, J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Furby, J.
Thompson, A. J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, England
UCL, Dept Brain Repair & Rehabil, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Thompson, A. J.
Miller, D. H.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
Miller, D. H.
Chard, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
UCL, MS Nucl Magnet Res Unit, Inst Neurol, London WC1N 3BG, EnglandUCL, Dept Neuroinflammat, Inst Neurol, London WC1N 3BG, England
机构:
Univ Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, EnglandUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Horsfield, Mark A.
Sala, Stefania
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Sala, Stefania
Neema, Mohit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Neema, Mohit
Absinta, Martina
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Absinta, Martina
Bakshi, Anshika
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Bakshi, Anshika
Sormani, Maria Pia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Genoa, Dept Hlth Sci DISSAL, Biostat Unit, Genoa, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Sormani, Maria Pia
Rocca, Maria A.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Rocca, Maria A.
Bakshi, Rohit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol,Partners MS Ctr,Lab Neuroimaging Res, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USAUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England
Bakshi, Rohit
Filippi, Massimo
论文数: 0引用数: 0
h-index: 0
机构:
Inst Sci, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, Milan, Italy
Univ Osped San Raffaele, Milan, ItalyUniv Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Med Phys Grp, Leicester LE1 5WW, Leics, England