Comparisons of therapeutic outcomes in patients with nonampullary duodenal neuroendocrine tumors (NADNETs) A multicenter retrospective study

被引：26

作者：

Lee, Seung Woo ^{[1
]}

Sung, Jae Kyu ^{[2
]}

Cho, Young Sin ^{[3
]}

Bang, Ki Bae ^{[4
]}

Kang, Sun Hyung ^{[2
]}

Kim, Ki Bae ^{[5
]}

Kim, Sae Hee ^{[6
]}

Moon, Hee Seok ^{[2
]}

Song, Kyung Ho ^{[7
]}

Kim, Sun Moon ^{[7
]}

Chung, Il-Kwun ^{[3
]}

Lee, Dong Soo ^{[1
]}

Jeong, Hyun Yong ^{[2
]}

Youn, Sei Jin ^{[5
]}

机构：

[1] Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Coll Med,Daejeon St Marys Hosp, Seoul, South Korea

[2] Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon, South Korea

[3] Soonchunhyang Univ, Dept Internal Med, Cheonan Hosp, Div Gastroenterol,Coll Med, Cheonan, South Korea

[4] Dankook Univ, Dept Internal Med, Coll Med, Yongin, South Korea

[5] Chungbuk Natl Univ, Sch Med, Dept Internal Med, Cheongju, South Korea

[6] Eulji Univ, Dept Internal Med, Coll Med, Seongnam, Gyeonggi, South Korea

[7] Konyang Univ, Dept Internal Med, Coll Med, Nonsan, South Korea

来源：

MEDICINE | 2019年 / 98卷 / 26期

关键词：

duodenum; endoscopic resection; neuroendocrine tumor; surgery; treatment; CARCINOID-TUMORS; ENDOSCOPIC RESECTION; RISK-FACTORS;

D O I：

10.1097/MD.0000000000016154

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Duodenal neuroendocrine tumors (DNETs) are rare tumors that are occasionally found during upper endoscopies. The incidence of DNETs is increasing, although the data regarding treatment outcomes are insufficient. The aim of this study was to evaluate the treatment outcomes in patients with nonampullary DNETs who underwent endoscopic resection or surgery. We evaluated the medical records of patients who were diagnosed with nonampullary DNETs from 2004 to 2017 in 7 university hospitals. We retrospectively analyzed clinical characteristics and compared therapeutic outcomes based on the endoscopic lesion size and treatment method. We ultimately enrolled 60 patients with nonampullary DNETs who underwent endoscopic and surgical treatments. In the endoscopic treatment group, the en bloc resection, endoscopic complete resection (CR) and pathologic CR rates were 88%, 92%, and 50%, respectively. The endoscopic treatment group was divided into 3 subgroups based on the lesion size (1-5 mm, 6-10 mm, and >= 11 mm). The pathologic CR rate was significantly lower in the subgroup with a lesion size >= 11 mm (0%, P=.003) than those in the other 2 subgroups. Lymphovascular invasion occurred significantly more frequently (33.3%, P=.043) among those with a lesion size >= 11 mm. The pathologic CR rate in the surgical treatment group was higher (90.9%) than that in the endoscopic treatment group (50%, P=.017). Surgical treatment appears to be a more appropriate choice because of the risks of incomplete resection and lymphovascular invasion after endoscopic treatment for lesions larger than 11 mm.

引用

页数：8

共 21 条

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