Codon 219 in Creutzfeldt-Jakob disease in Poland

被引：0
作者：
Bratosiewiez-Wasik, J
Wasik, TJ
Liberski, PP [1 ]
机构：
[1] Med Univ Silesia, Dept Virol Diagnost, Chair Mol Biol Biochem & Biopharm, Katowice, Poland
[2] Med Acad Lodz, Chair Oncol, Dept Mol Biol, Lab Neuropathol & Electron Microscopy, Lodz, Poland
来源：
ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2002年 / 62卷 / 03期
关键词：
Creutzfeldt-Jakob disease; prion protein; prion protein gene sequence;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Prion diseases are a group of etiologically heterogenous diseases. In addition to familial cases linked to mutations of PRNP open reading frame they include also cases of unknown etiology. One of the susceptibility factors to sporadic as well as iatrogenic prion diseases are PRNP polymorphisms. In the present study, we analyzed sequences of the PRNP gene codon 219 of 16 Polish CJD cases and we found heterozygous GAG to GAT changes on the sense strand and only wild type sequence on an antisense strand. The RFLP technique was used to verify this divergence and only wild type sequences were revealed.
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页码：149 / 151
页数：3
相关论文
共 12 条
  • [1] Iatrogenic Creutzfeldt-Jakob disease at the millennium
    Brown, P
    Preece, M
    Brandel, JP
    Sato, T
    McShane, L
    Zerr, I
    Fletcher, A
    Will, RG
    Pocchiari, M
    Cashman, NR
    d'Aignaux, JH
    Cervenáková, L
    Fradkin, J
    Schonberger, LB
    Collins, SJ
    [J]. NEUROLOGY, 2000, 55 (08) : 1075 - 1081
  • [2] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
    Collinge, J
    Sidle, KCL
    Meads, J
    Ironside, J
    Hill, AF
    [J]. NATURE, 1996, 383 (6602) : 685 - 690
  • [3] GENETIC PREDISPOSITION TO IATROGENIC CREUTZFELDT-JAKOB DISEASE
    COLLINGE, J
    PALMER, MS
    DRYDEN, AJ
    [J]. LANCET, 1991, 337 (8755) : 1441 - 1442
  • [4] Prion diseases of humans and animals: Their causes and molecular basis
    Collinge, J
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 : 519 - 550
  • [5] Genotype at codon 129 and susceptibility to Creutzfeldt-Jakob disease
    Deslys, JP
    Jaegly, A
    d'Aignaux, JH
    Mouthon, F
    de Villemeur, TB
    Dormont, D
    [J]. LANCET, 1998, 351 (9111) : 1251 - 1251
  • [6] NEW VARIANT PRION PROTEIN IN A JAPANESE FAMILY WITH GERSTMANN-STRAUSSLER SYNDROME
    FURUKAWA, H
    KITAMOTO, T
    TANAKA, Y
    TATEISHI, J
    [J]. MOLECULAR BRAIN RESEARCH, 1995, 30 (02): : 385 - 388
  • [7] GOLDFARB L G, 1989, American Journal of Human Genetics, V45, pA189
  • [8] OWEN F, 1989, NUCLEIC ACIDS RES, V18, P3103
  • [9] HOMOZYGOUS PRION PROTEIN GENOTYPE PREDISPOSES TO SPORADIC CREUTZFELDT-JAKOB DISEASE
    PALMER, MS
    DRYDEN, AJ
    HUGHES, JT
    COLLINGE, J
    [J]. NATURE, 1991, 352 (6333) : 340 - 342
  • [10] SALVATORE M, 1994, HUM GENET, V94, P375, DOI 10.1007/BF00201596
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