Copper-catalyzed C-N coupling/C-H functionalization: A tandem approach to azole-fused quinazoline derivatives

被引：17

作者：

Chen, Dingben ^{[1
]}

Huang, Ling ^{[1
]}

Yang, Jianguo ^{[1
]}

Ma, Junna ^{[1
]}

Zheng, Yingying ^{[1
]}

Luo, Yi ^{[1
]}

Shen, Yang ^{[1
]}

Wu, Jiashou ^{[1
]}

Feng, Chao ^{[3
]}

Lv, Xin ^{[2
]}

机构：

[1] Taizhou Univ, Coll Pharmaceut & Chem Engn, Taizhou 318000, Zhejiang, Peoples R China

[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Chem, Jinhua 321004, Peoples R China

[3] Univ Pacific, Dept Chem, Stockton, CA 95211 USA

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 21期

关键词：

Azole-fused quinazoline; Cascade reaction; Cu-catalyzed reaction; C-N coupling; C-H functionalization; ONE-POT SYNTHESIS; CASCADE SYNTHESES; BOND FORMATION; AMINATION; ARYLATION; QUINOXALIN-2(1H)-ONES; CYCLIZATION; ACTIVATION; AGENTS; ROUTE;

D O I：

10.1016/j.tetlet.2018.04.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Cu-catalyzed tandem synthesis of azole-fused pyrimido[1,2-c]quinazolines and imidazo[1,2-c]quinazolines has been developed. The reaction is based on a C-N cross-coupling/C-H functionalization reaction of 2-(2-bromophenyl)-1,4,5,6-tetrahydropyrimidines with azoles. A variety of the desired polycyclic products were obtained in moderate to excellent yields. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2005 / 2009

页数：5

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