Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver

被引：7
|
作者：
Sidorova, YA [1 ]
Grishanova, AY [1 ]
机构：
[1] Russian Acad Med Sci, Lab Biochem Foreign Cpds, Inst Mol Biol & Biophys, Siberian Div, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
menadione; vitamin K-3; CYP1A; CYP2B; CYP2C; NADPH-cytochrome P450 reductase; glutathione S-transferase;
D O I：
10.1023/B:BEBM.0000031556.47763.04
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of synthetic vitamin K analogue menadione on enzymes of xenobiotic metabolism in rat liver (total content of cytochrome P450 and catalytic activities of CYPIA1/2, CYP2B1, CYP2C, NADPH-cytochrome P450 reductase, and glutathione S-transferase). Menadione induced phase I and 11 enzymes for metabolism of xenobiotics, drugs, and pro-carcinogens. The effect of menadione depended on its dose and duration of treatment.
引用
收藏
页码：231 / 234
页数：4
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