The antiphospholipid syndrome may induce non-thrombotic internal jugular vein stenosis: two cases report

被引：3

作者：

Song, Si-ying ^{[1
,2
,3
]}

Rajah, Gary ^{[3
,4
]}

Ding, Yu-chuan ^{[3
,5
]}

Ji, Xun-ming ^{[2
,3
]}

Meng, Ran ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Chang Chun Rd 45, Beijing, Peoples R China

[2] Beijing Inst Brain Disorders, Adv Ctr Stroke, Beijing 100053, Peoples R China

[3] Capital Med Univ, Xuanwu Hosp, Dept China Amer, Inst Neurosci, Beijing 100053, Peoples R China

[4] SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Neurosurg, Buffalo, NY USA

[5] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI 48201 USA

来源：

BMC NEUROLOGY | 2021年 / 21卷 / 01期

基金：

国家重点研发计划;

关键词：

Antiphospholipid syndrome; Non-thrombotic internal jugular vein stenosis; Neuroimaging; Case report; ANTIBODIES;

D O I：

10.1186/s12883-020-02035-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported. Case presentation: This study described two cases of young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literature on this issue, including clinical features, diagnosis, and treatment. Conclusions: IJVS is a rather rare complication of APS. Two cases were reported for the first time that high titer of antiphospholipid antibodies (aPL) might mediate direct vessel wall damage and further induce venous stenosis despite long-term standardized anticoagulation to prevent thrombus formation. Therefore, dynamic monitoring of autoantibodies and concomitant use of anticoagulants and corticosteroids may be necessary to the management of APS and its complications.

引用

页数：8