Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

被引：32
|
作者：
Ma, Luoyang [1 ,2 ]
Zheng, Xiaoyan [1 ,3 ]
Lin, Rui [1 ]
Sun, Antonia Rujia [4 ]
Song, Jintong [1 ]
Ye, Zhiqiang [1 ]
Liang, Dahong [1 ]
Zhang, Min [1 ]
Tian, Jia [1 ]
Zhou, Xin [2 ]
Cui, Liao [1 ]
Liu, Yuyu [1 ]
Liu, Yanzhi [1 ,3 ,5 ]
机构：
[1] Pharm Guangdong Med, Guangdong Prov Key Lab Res & Dev Nat Drug, Sch Pharm, Zhanjiang City 524023, Guangdong, Peoples R China
[2] Marine Med Res Inst Zhanjiang, Zhanjiang City 524023, Guangdong, Peoples R China
[3] Guangdong Med Univ, Zhanjiang Cent Hosp, Zhanjiang City 524045, Guangdong, Peoples R China
[4] Chinese Acad Sci, Ctr Translat Med Res & Dev, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China
[5] Shenzhen Osteomore Biotechnol Co Ltd, Shenzhen 518118, Guangdong, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2022年 / 16卷
基金：
中国国家自然科学基金;
关键词：
osteoarthritis; knee; drug delivery; intra-articular; INJECTABLE THERMOSENSITIVE HYDROGEL; HYALURONIC-ACID HYDROGEL; RHEUMATOID-ARTHRITIS; CARTILAGE DAMAGE; CHONDROGENIC DIFFERENTIATION; TARGETED NANOSOMES; POLYMERIC MICELLES; CARBON NANOTUBES; IN-VITRO; FAT PAD;
D O I：
10.2147/DDDT.S357386
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.
引用
收藏
页码：1311 / 1347
页数：37
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