DNA double-strand breaks in meiosis: Checking their formation, processing and repair

被引：68

作者：

Longhese, Maria Pia ^{[1
]}

Bonetti, Diego ^{[1
]}

Guerini, Ilaria ^{[1
]}

Manfrini, Nicola ^{[1
]}

Clerici, Michela ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dipartimento Biotecnol & Biosci, I-20126 Milan, Italy

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

关键词：

Double-strand breaks; Meiosis; Checkpoint; CDK; Mek1; Rad53; MEIOTIC RECOMBINATION CHECKPOINT; HOMOLOGOUS CHROMOSOME SYNAPSIS; DAMAGE RESPONSE PATHWAY; BUDDING YEAST SAE2; SACCHAROMYCES-CEREVISIAE; CELL-CYCLE; SYNAPTONEMAL COMPLEX; S-PHASE; MRE11; COMPLEX; FISSION YEAST;

D O I：

10.1016/j.dnarep.2009.04.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination. (C) 2009 Elsevier B.V. All rights reserved.

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收藏

页码：1127 / 1138

页数：12

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