Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network

被引：25

作者：

Darlix, Amelie ^{[1
]}

Mandonnet, Emmanuel ^{[2
]}

Freyschlag, Christian F. ^{[3
]}

Pinggera, Daniel ^{[3
]}

Forster, Marie-Therese ^{[4
]}

Voss, Martin ^{[5
]}

Steinbach, Joachim ^{[5
]}

Loughrey, Carmel ^{[6
]}

Goodden, John ^{[6
,7
]}

Banna, Giuseppe ^{[8
]}

Di Blasi, Concetta ^{[8
]}

Foroglou, Nicolas ^{[9
]}

Hottinger, Andreas F. ^{[10
,11
,12
]}

Baron, Marie-Helene ^{[13
]}

Pallud, Johan ^{[14
,15
]}

Duffau, Hugues ^{[16
,17
]}

Rutten, Geert-Jan ^{[18
]}

Almairac, Fabien ^{[19
]}

Fontaine, Denys ^{[19
]}

Taillandier, Luc ^{[20
]}

Viegas, Catarina Pessanha ^{[21
]}

Albuquerque, Luisa ^{[21
]}

von Campe, Gord ^{[22
]}

Urbanic-Purkart, Tadeja ^{[22
]}

Blonski, Marie ^{[20
]}

机构：

[1] Univ Montpellier, Inst Canc Montpellier, Dept Med Oncol, 208 Ave Apothicaires, F-34298 Montpellier, France

[2] Lariboisiere Hosp, AP HP, Dept Neurosurg, Paris, France

[3] Med Univ Innsbruck, Dept Neurosurg, Innsbruck, Austria

[4] Goethe Univ Hosp, Dept Neurosurg, Frankfurt, Germany

[5] Goethe Univ Hosp, Dr Senckenberg Inst Neurooncol, Frankfurt, Germany

[6] Leeds Gen Infirm, Leeds, W Yorkshire, England

[7] North East Paediat Neurosci Network, Leeds, W Yorkshire, England

[8] Cannizzaro Gen Hosp, Dept Neurosurg & Gammaknife, Catania, Italy

[9] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurosurg, Thessaloniki, Greece

[10] CHU Vaudois, Dept Clin Neurosci, Lausanne, Switzerland

[11] CHU Vaudois, Dept Oncol, Lausanne, Switzerland

[12] Lausanne Univ, Lausanne, Switzerland

[13] Besancon Univ Hosp, Dept Radiotherapy, Besancon, France

[14] St Anne Hosp, Dept Neurosurg, Paris, France

[15] Paris Descartes Univ, Sorbonne Paris Cite, Paris, France

[16] INSERM, U894, IMA Brain, Ctr Psychiat & Neurosci, Paris, France

[17] Montpellier Univ Hosp, Dept Neurosurg, Montpellier, France

[18] Elisabeth Tweesteden Hosp, Dept Neurosurg, Tilburg, Netherlands

[19] Univ Hosp Nice, Dept Neurosurg, Nice, France

[20] Nancy Neurol Hosp, Dept Neurooncol, Nancy, France

[21] Hosp Garcia Orta, Almada, Portugal

[22] Med Univ Graz, Dept Neurosurg, Graz, Austria

来源：

NEURO-ONCOLOGY PRACTICE | 2019年 / 6卷 / 04期

关键词：

diffuse low-grade glioma; clinical practice; chemotherapy; PCV; temozolomide; QUALITY-OF-LIFE; LONG-TERM OUTCOMES; TEMOZOLOMIDE CHEMOTHERAPY; PROGNOSTIC-FACTORS; RADIATION-THERAPY; EORTC; 22033-26033; PCV CHEMOTHERAPY; II GLIOMAS; OPEN-LABEL; PHASE-II;

D O I：

10.1093/nop/npy051

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background. Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial. Methods. An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients. Results. The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression. Conclusions. The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues.

引用

页码：264 / 273

页数：10

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