The DRD2 gene and the risk for alcohol dependence in bipolar patients

被引:20
作者
Gorwood, P
Bellivier, F
Adès, J
Leboyer, M
机构
[1] Hop Louis Mourier, Serv Psychiat Adulte Prof Ades, F-92700 Colombes, France
[2] Lab Personnal & Conduites Adaptat Prof Jouvent, CNRS UMR 7593, Paris, France
[3] Hop Albert Chenevier & Henri Mondor, AP HP, Serv Psychiat Adulte Prof Rouillon, F-94000 Creteil, France
[4] INSERM U513, Lab Neurobiol & Psychiat, F-94000 Creteil, France
关键词
alcoholism; co-morbidity; genetics; mood disorder;
D O I
10.1016/S0924-9338(00)00205-4
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The high co-morbidity between bipolar disorder and alcohol dependence may have different explanations, one of them being the existence of common genetic factors for the two disorders. Several candidate genes may be involved but the genes acting in the dopaminergic pathway may be more specifically involved. We have thus tested the role of the gene encoding the D2 dopamine receptor (Taql Al allele) in the potentially shared vulnerability to alcohol dependence and bipolar disorder. One hundred and twenty-two French (for at least two generations) patients were recruited on the basis of hospital or outpatient files and were interviewed with the DIGS. The Al allele frequencies were compared between four groups, namely, with bipolar patients and co-morbid alcohol dependence (N = 21), with bipolar patients without alcohol morbidity (N = 31), with alcohol dependence without mood disorder (N = 35) and unaffected controls (N = 35). The Hardy Weinberg equilibrium for the DRD2 Taql Al genotypes was respected for the sample as a whole, and for each subsample. We observed that 42.9% of control subjects have at least one Al allele, a frequency which is not significantly different from the one observed in the affected sample as a whole (39.1%), neither from patients with alcohol dependence (37.1%), patients with bipolar disorder (48.4%) nor patients with alcohol dependence and bipolar disorder (28.6%). The regression analysis based on the three variables (bipolar disorder, alcohol dependence and interaction between these two disorders) does not explain the presence of the Al allele of the DRD2 gene. We thus found no evidence for a significant role of the Al allele of the D2 dopamine receptor gene in the specific association between bipolar disorder and alcohol dependence in our sample. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:103 / 108
页数:6
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[31]   Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence [J].
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[32]   GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence [J].
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[37]   Modulation of nicotine effects on selective attention by DRD2 and CHRNA4 gene polymorphisms [J].
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[38]   Why different rules are required for polygenic inheritance:: Lessons from studies of the DRD2 gene [J].
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ALCOHOL, 1998, 16 (01) :61-70
[39]   Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism [J].
Finckh, U ;
Rommelspacher, H ;
Kuhn, S ;
Dufeu, P ;
Otto, G ;
Heinz, A ;
Dettling, M ;
GiraldoVelasquez, M ;
Pelz, J ;
Graf, KJ ;
Harms, H ;
Sander, T ;
Schmidt, LG ;
Rolfs, A .
PHARMACOGENETICS, 1997, 7 (04) :271-281
[40]   Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking [J].
Bierut, LJ ;
Rice, JP ;
Edenberg, HJ ;
Goate, A ;
Foroud, T ;
Cloninger, CR ;
Begleiter, H ;
Conneally, PM ;
Crowe, RR ;
Hesselbrock, V ;
Li, TK ;
Nurnberger, JI ;
Porjesz, B ;
Schuckit, MA ;
Reich, T .
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