A new approach to natural products discovery exemplified by the identification of sulfated nucleosides in spider venom

被引：67
|
作者：
Taggi, AE
Meinwald, J
Schroeder, FC [1 ]
机构：
[1] Cornell Univ, Cornell Inst Res Chem Ecol, Ithaca, NY 14853 USA
[2] Cornell Univ, Dept Chem & Chem Biol, Baker Lab, Ithaca, NY 14853 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 33期
关键词：
D O I：
10.1021/ja047416n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Using a new approach based on the NMR spectroscopic analysis of the entire, unpurified spider venom, we identified a family of unusual sulfated nucleoside derivatives from the venom of the hobo spider, Tegenaria agrestis. These compounds are ribonucleoside mono- and disulfates derived from guanosine and xanthosine, some of which are glycosylated, bearing one or two D-fucose units. The use of NMR spectroscopy to characterize the unfractionated venom was central to the discovery of this heretofore overlooked class of venom components.
引用
收藏
页码：10364 / 10369
页数：6
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