Soluble Receptor for Advanced Glycation End Products (sRAGE) is Up-Regulated in Multiple Sclerosis Patients Treated with Interferon β-1a

被引：12
作者：
Rahimi, Mahnoosh [1 ]
Afjeh, Sarah Saadat Aghabozorg [1 ]
Omrani, Mir Davood [1 ,2 ]
Arsang-Jang, Shahram [3 ]
Ganji, Maziar [1 ]
Noroozi, Rezvan [4 ]
Taheri, Mohammad [1 ,2 ]
Ghafouri-Fard, Soudeh [1 ,2 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran 1985717443, Iran
[2] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
[3] Qom Univ Med Sci, Dept Biostat & Epidemiol, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 46卷 / 02期
关键词：
sRAGE; Multiple sclerosis; VASCULAR INFLAMMATION; DISEASE SEVERITY; RAGE; EXPRESSION;
D O I：
10.1159/000488622
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Considering the role of immune system in its pathogenesis, researchers have focused on evaluation of the expression of immune-related genes or proteins in MS patients. Among proteins whose participation in inflammatory process has been documented is the receptor for advanced glycation end products (RAGE). Methods: In the present study, we compared RAGE transcript levels by means of quantitative real-time PCR as well as the serum level of soluble RAGE (sRAGE) by means of enzyme-linked immunosorbent assay (ELISA) in 50 IFN beta-1a responsive relapsing-remitting MS patients when compared with age and sexmatched healthy subjects. Results: Elevated expression of RAGE as well as higher levels of sRAGE were detected in IFN-beta responsive MS patients compared with the controls. A significant inverse correlation between sRAGE plasma concentrations and the expanded disability status scale (EDSS) was also detected in which each unit of increase in sRAGE level resulted in a 0.308 unit decrease in EDSS. Conclusion: Considering the stable clinical state of the MS patients in this study and their response to IFN beta-1a, the elevated levels of sRAGE in patients compared with healthy subjects could be related to the effects of this kind of treatment. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：561 / 567
页数：7
相关论文
共 24 条
[1]   Interferon-β 1a Modulates Expression of RAGE but Not S100A12 and Nuclear Factor-κB in Multiple Sclerosis Patients [J].
Asadikaram, Gholamreza ;
Noroozi, Saam ;
Meimand, Hossein Ali Ebrahimi ;
Sanjari, Mojgan ;
Zainodini, Nahid ;
Khoramdelazad, Hossein ;
Shahrokhi, Nader ;
Arababadi, Mohammad Kazemi .
NEUROIMMUNOMODULATION, 2016, 23 (5-6) :345-351
[2]   Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation [J].
Bodine, B. Garrett ;
Bennion, Brock G. ;
Leatham, Emma ;
Jimenez, Felix R. ;
Wright, Alex J. ;
Jergensen, Zac R. ;
Erickson, Connor J. ;
Jones, Cameron M. ;
Johnson, Jeff P. ;
Knapp, Steven M. ;
Reynolds, Paul R. .
RESPIRATORY RESEARCH, 2014, 15
[3]  
BRETT J, 1993, AM J PATHOL, V143, P1699
[4]   Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases [J].
Chuah, Yaw Kuang ;
Basir, Rusliza ;
Talib, Herni ;
Tie, Tung Hing ;
Nordin, Norshariza .
INTERNATIONAL JOURNAL OF INFLAMMATION, 2013, 2013
[5]   sRage plasma level in association with multiple sclerosis risk in Slovak population [J].
Dobrota, Dusan ;
Cierny, Daniel ;
Michalik, Jozef ;
Kurca, Egon ;
Lehotsky, Jan .
SPRINGERPLUS, 2015, 4
[6]   Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients [J].
Eftekharian, Mohammad Mahdi ;
Ghafouri-Fard, Soudeh ;
Soudyab, Mohammad ;
Omrani, Mir Davood ;
Rahimi, Mahnoosh ;
Sayad, Arezou ;
Komaki, Alireza ;
Mazdeh, Mehrdokht ;
Taheri, Mohammad .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2017, 63 (3-4) :333-341
[7]   Phospholipase D1 expression analysis in relapsing-remitting multiple sclerosis patients [J].
Eftekharian, Mohammad Mahdi ;
Azimi, Tahereh ;
Ghafouri-Fard, Soudeh ;
Sayad, Arezou ;
Omrani, Mir Davood ;
Sarrafzadeh, Shaghayegh ;
Abbasalipourkabir, Roghayeh ;
Mazdeh, Mehrdokht ;
Taheri, Mohammad .
NEUROLOGICAL SCIENCES, 2017, 38 (05) :865-872
[8]   Decreased Level of sRAGE in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset [J].
Glasnovic, Anton ;
Cvija, Hrvoje ;
Stojic, Maristela ;
Tudoric-Deno, Ivana ;
Ivcevic, Sanja ;
Romic, Dominik ;
Ticinovic, Nino ;
Vuletic, Vladimira ;
Lazibat, Ines ;
Grcevic, Danka .
NEUROIMMUNOMODULATION, 2014, 21 (05) :226-233
[9]   Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD [J].
Gopal, Poornima ;
Reynaert, Niki L. ;
Scheijen, Jean L. J. M. ;
Schalkwijk, Casper G. ;
Franssen, Frits M. E. ;
Wouters, Emiel F. M. ;
Rutten, Erica P. A. .
RESPIRATORY RESEARCH, 2014, 15
[10]   Alternative splicing of RAGE: roles in biology and disease [J].
Kalea, Anastasia Z. ;
Schmidt, Ann Marie ;
Hudson, Barry I. .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 :2756-2770
123