Quantification of tenofovir disoproxil fumarate and emtricitabine in generic pre-exposure prophylaxis tablets obtained from the internet

被引：2
作者：
Wang, Xinzhu [1 ]
Nutland, Will [2 ]
Brady, Michael [3 ]
Green, Ian [3 ]
Boffito, Marta [1 ,4 ]
McClure, Myra [1 ]
机构：
[1] Imperial Coll London, Dept Med, London, England
[2] PrEPster, London, England
[3] Terrence Higgins Trust, London, England
[4] Chelsea & Westminster Hosp, HIV GUM Dept, London, England
来源：
INTERNATIONAL JOURNAL OF STD & AIDS | 2019年 / 30卷 / 08期
关键词：
Generic PrEP; HIV prevention; liquid chromatography; quantification; tablet form; MEN;
D O I：
10.1177/0956462419841144
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, we addressed the recent concerns over the authenticity of generic pre-exposure prophylaxis (PrEP) purchased online by sampling 14 generic PrEPs from different manufacturers and suppliers and measuring tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) content using high-performance liquid chromatography. We confirmed that all the PrEP tablets contained 94.3% to 104.9% of the 300 mg of TDF claimed on the label and 97.3% to 104.4% of the 200 mg FTC claimed on the label.
引用
收藏
页码：765 / 768
页数：4
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