Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys

被引：37

作者：

Li, Xian

Xiao, Weilie

Pu, Jianxin

Ban, Lili

Shen, Yunheng

Weng, Zhiying

Li, Shenghong

Sun, Handong

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Kunming Med Coll, Acad Pharmacol, Kunming 650031, Yunnan, Peoples R China

[3] Kunming Med Coll, Yunnan Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 13期

关键词：

Isodon phyllostachys; Labiatae; ent-kaurenoids; phyllostachysins D-H; cytotoxic effect;

D O I：

10.1016/j.phytochem.2006.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic methods, especially using 2D-NMR spectroscopic analyses. All ent-kaurenoids were tested for their cytotoxic effects against K562 cells. Compound 9 was the most potent with an IC50 value of 0.69 mu g/ml. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1336 / 1340

页数：5

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