Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations

被引:94
作者
Agrawal, Pawan K. [1 ]
Agrawal, Chandan [1 ]
Blunden, Gerald [2 ]
机构
[1] Nat Prod Inc, 7963 Anderson Pk Lane, Westerville, OH 43081 USA
[2] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England
关键词
Quercetin; flavonoids; antiviral; COVID-19; integrative considerations; RESPIRATORY SYNDROME CORONAVIRUS; MENGO-VIRUS INFECTION; HEPATITIS-C VIRUS; IN-VITRO; FLAVONOID QUERCETIN; SARS-CORONAVIRUS; INHIBITION; POLYPHENOLS; SUPPLEMENTATION; EXPRESSION;
D O I
10.1177/1934578X20976293
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry and replication cycle such as PLpro, 3CLpro, and NTPase/helicase. Due to its pleiotropic activities and lack of systemic toxicity, quercetin and its derivatives may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. There is evidence that quercetin in combination with, for example, vitamins C and D, may exert a synergistic antiviral action that may provide either an alternative or additional therapeutic/preventive option due to overlapping antiviral and immunomodulatory properties. This review summarizes the antiviral significance of quercetin and proposes a possible strategy for the effective utilization of natural polyphenols in our daily diet for the prevention of viral infection.
引用
收藏
页数:10
相关论文
共 156 条
[1]   Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats [J].
Abdelmoaty M.A. ;
Ibrahim M.A. ;
Ahmed N.S. ;
Abdelaziz M.A. .
Indian Journal of Clinical Biochemistry, 2010, 25 (2) :188-192
[2]   Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening [J].
Abian, Olga ;
Ortega-Alarcon, David ;
Jimenez-Alesanco, Ana ;
Ceballos-Laita, Laura ;
Vega, Sonia ;
Reyburn, Hugh T. ;
Rizzuti, Bruno ;
Velazquez-Campoy, Adrian .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 :1693-1703
[3]  
Aguirre L., 2011, The Open Nutraceuticals Journal, V4, DOI [DOI 10.2174/1876396001104010189, 10.2174/1876396001104010189]
[4]  
Ahmed A K., 2020, Int J of End and Diabe, V1, P018
[5]   Integrative considerations during the COVID-19 pandemic [J].
Alschuler, Lise ;
Weil, Andrew ;
Horwitz, Randy ;
Stamets, Paul ;
Chiasson, Ann Marie ;
Crocker, Robert ;
Maizes, Victoria .
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING, 2020, 16 (06) :354-356
[6]  
Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044
[7]   Safety Aspects of the Use of Quercetin as a Dietary Supplement [J].
Andres, Susanne ;
Pevny, Sophie ;
Ziegenhagen, Rainer ;
Bakhiya, Nadiya ;
Schaefer, Bernd ;
Hirsch-Ernst, Karen Ildico ;
Lampen, Alfonso .
MOLECULAR NUTRITION & FOOD RESEARCH, 2018, 62 (01)
[8]  
[Anonymous], 2020, NATURE, DOI DOI 10.1038/s41586-020-2012-7
[9]   EFFECT OF ASCORBIC-ACID ON INFECTION OF CHICK-EMBRYO CILIATED TRACHEAL ORGAN-CULTURES BY CORONAVIRUS [J].
ATHERTON, JG ;
KRATZING, CC ;
FISHER, A .
ARCHIVES OF VIROLOGY, 1978, 56 (03) :195-199
[10]   Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts [J].
Awad, HM ;
Boersma, MG ;
Vervoort, J ;
Rietjens, IMCM .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 378 (02) :224-233