Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases

被引：0
作者：
Maruszak, Aleksandra
Gaweda-Walerych, Katarzyna
Soltyszewski, Ireneusz
Kekanowski, Cezary
机构：
[1] Polish Acad Sci, Med Res Ctr, Dept Neurodegenerat Disorders, PL-02106 Warsaw, Poland
[2] Cent Forens Lab Police, Dept Biol, PL-00735 Warsaw, Poland
[3] Univ Warmia & Mazury, Dept Criminalist & Forens Med, PL-10702 Olsztyn, Poland
[4] Int Inst Mol & Cell Biol, Lab Neurodegenerat, PL-02109 Warsaw, Poland
来源：
ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2006年 / 66卷 / 02期
关键词：
mitochondrial DNA; Alzheimer's disease; Parkinson's disease; haplogroups; single nucleotide polymorphisms; neurodegeneration;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions.
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页码：153 / 176
页数：24
相关论文
共 166 条
[11]   Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach [J].
Behl, C ;
Moosmann, B .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (02) :182-191
[12]   High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease [J].
Bender, A ;
Krishnan, KJ ;
Morris, CM ;
Taylor, GA ;
Reeve, AK ;
Perry, RH ;
Jaros, E ;
Hersheson, JS ;
Betts, J ;
Klopstock, T ;
Taylor, RW ;
Turnbull, DM .
NATURE GENETICS, 2006, 38 (05) :515-517
[13]   Mitochondrial DNA in aging and degenerative disease [J].
Berdanier, CD ;
Everts, HB .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) :169-184
[14]   Intersecting pathways to neurodegeneration in Parkinson's disease:: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system [J].
Betarbet, R ;
Canet-Aviles, RA ;
Sherer, TB ;
Mastroberardino, PG ;
McLendon, C ;
Kim, JH ;
Lund, S ;
Na, HM ;
Taylor, G ;
Bence, NF ;
Kopito, R ;
Seo, BB ;
Yagi, T ;
Klinefelter, G ;
Cookson, MR ;
Greenamyre, JT .
NEUROBIOLOGY OF DISEASE, 2006, 22 (02) :404-420
[15]   Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].
Betarbet, R ;
Sherer, TB ;
MacKenzie, G ;
Garcia-Osuna, M ;
Panov, AV ;
Greenamyre, JT .
NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306
[16]   Animal models of Parkinson's disease [J].
Betarbet, R ;
Sherer, TB ;
Greenamyre, JT .
BIOESSAYS, 2002, 24 (04) :308-318
[17]   Early-onset parkinsonism associated with PINK1 mutations -: Frequency, genotypes, and phenotypes [J].
Bonifati, V ;
Rohé, CF ;
Breedveld, GJ ;
Fabrizio, E ;
De Mari, M ;
Tassorelli, C ;
Tavella, A ;
Marconi, R ;
Nicholl, DJ ;
Chien, HF ;
Fincati, E ;
Abbruzzese, G ;
Marini, P ;
De Gaetano, A ;
Horstink, MW ;
Maat-Kievit, JA ;
Sampaio, C ;
Antonini, A ;
Stocchi, F ;
Montagna, P ;
Toni, V ;
Guidi, M ;
Dalla Libera, A ;
Tinazzi, M ;
De Pandis, F ;
Fabbrini, G ;
Goldwurm, S ;
de Klein, A ;
Barbosa, E ;
Lopiano, L ;
Martignoni, E ;
Lamberti, P ;
Vanacore, N ;
Meco, G ;
Oostra, BA .
NEUROLOGY, 2005, 65 (01) :87-95
[18]   Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].
Bonifati, V ;
Rizzu, P ;
van Baren, MJ ;
Schaap, O ;
Breedveld, GJ ;
Krieger, E ;
Dekker, MCJ ;
Squitieri, F ;
Ibanez, P ;
Joosse, M ;
van Dongen, JW ;
Vanacore, N ;
van Swieten, JC ;
Brice, A ;
Meco, G ;
van Duijn, CM ;
Oostra, BA ;
Heutink, P .
SCIENCE, 2003, 299 (5604) :256-259
[19]   Mitochondrial involvement in Alzheimer's disease [J].
Bonilla, E ;
Tanji, K ;
Hirano, M ;
Vu, TH ;
DiMauro, S ;
Schon, EA .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1410 (02) :171-182
[20]  
Brown MD, 1996, AM J MED GENET, V61, P283, DOI 10.1002/(SICI)1096-8628(19960122)61:3<283::AID-AJMG15>3.0.CO
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