Prognostic value of the miR-200 family in bladder cancer A systematic review and meta-analysis

被引：13
作者：
Mei, Yanhui [1 ,2 ]
Zheng, Jianbo [3 ]
Xiang, Ping [4 ]
Liu, Cheng [5 ]
Fan, Yidong [1 ]
机构：
[1] Shandong Univ, Dept Urol, Qilu Hosp, 107 Wenhua Western Rd, Jinan 250012, Shandong, Peoples R China
[2] Binzhou Med Univ Hosp, Dept Urol, Binzhou, Peoples R China
[3] Zibo Cent Hosp, Dept Urol, Zibo, Shandong, Peoples R China
[4] Anhui Prov Hosp, Dept Urol, Hefei, Anhui, Peoples R China
[5] Peking Univ Third Hosp, Dept Urol, Beijing, Peoples R China
来源：
MEDICINE | 2020年 / 99卷 / 47期
关键词：
bladder cancer; meta-analysis; miR-200; family; prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; REPRESSORS ZEB1; MICRORNAS; RISK; PHENOTYPE; OUTCOMES; MARKERS; CELLS;
D O I：
10.1097/MD.0000000000022891
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: We aimed to evaluate the prognostic significance of high expression of the miR-200 family of microRNAs in bladder cancer. Methods: Studies on the correlation between the miR-200 family and prognosis in patients with bladder cancer were searched in databases. Combined hazard ratios (HRs) were calculated based on HRs and 95% confidence intervals (CIs) for overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS). Cochranes Q test and the I-2 statistic were utilized to assess heterogeneity across the included studies. Potential publication bias was analyzed by Begg and Egger tests. The meta-analysis was conducted using RevMan 5.3 and Stata SE12.0. Results: Data from a total of 1150 patients from 8 studies were extracted. The meta-analysis revealed that high expression of the miR-200 family was correlated with better OS (pooled hazard ratio: 0.50, 95% confidence interval: 0.40-0.62), CSS (pooled hazard ratio: 0.36, 95% confidence interval: 0.22-0.59) and RFS (pooled hazard ratio: 0.48, 95% confidence interval: 0.36-0.65). Both Begg test and Egger test verified no publication bias within the included cohorts. Conclusion: The high expression of the miR-200 family is strongly associated with better prognosis in bladder cancer patients, which will improve bladder cancer management in clinical practice.
引用
收藏
页数：8
相关论文
共 35 条
[1]   The Prognostic Role of Circulating Tumor Cells (CTC) in High-risk Nonemuscle-invasive Bladder Cancer [J].
Busetto, Gian Maria ;
Ferro, Matteo ;
Del Giudice, Francesco ;
Antonini, Gabriele ;
Chung, Benjamin I. ;
Sperduti, Isabella ;
Giannarelli, Diana ;
Lucarelli, Giuseppe ;
Borghesi, Marco ;
Musi, Gennaro ;
de Cobelli, Ottavio ;
De Berardinis, Ettore .
CLINICAL GENITOURINARY CANCER, 2017, 15 (04) :E661-E666
[2]   Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].
Calin, GA ;
Sevignani, C ;
Dan Dumitru, C ;
Hyslop, T ;
Noch, E ;
Yendamuri, S ;
Shimizu, M ;
Rattan, S ;
Bullrich, F ;
Negrini, M ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004
[3]   Systemic Inflammatory Markers and Oncologic Outcomes in Patients with High-risk Non-muscle-invasive Urothelial Bladder Cancer [J].
Cantiello, Francesco ;
Russo, Giorgio, I ;
Vartolomei, Mihai Dorin ;
Abu Farhan, Abdal Rahman ;
Terracciano, Daniela ;
Musi, Gennaro ;
Lucarelli, Giuseppe ;
Di Stasi, Savino M. ;
Hurle, Rodolfo ;
Serretta, Vincenzo ;
Busetto, Gian Maria ;
Scafuro, Chiara ;
Perdona, Sisto ;
Borghesi, Marco ;
Schiavina, Riccardo ;
Cioffi, Antonio ;
De Berardinis, Ettore ;
Almeida, Gilberto L. ;
Bove, Pierluigi ;
Lima, Estevao ;
Ucciero, Giuseppe ;
Matei, Deliu Victor ;
Crisan, Nicolae ;
Verzer, Paolo ;
Battaglia, Michele ;
Guazzoni, Giorgio ;
Autorino, Riccardo ;
Morgia, Giuseppe ;
Damiano, Rocco ;
de Cobelli, Ottavio ;
Mirone, Vincenzo ;
Shariat, Shahrokh F. ;
Ferro, Matteo .
EUROPEAN UROLOGY ONCOLOGY, 2018, 1 (05) :403-410
[4]   The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition [J].
Choi, Pui-Wah ;
Ng, Shu-Wing .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
[5]   Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis [J].
Davalos, V. ;
Moutinho, C. ;
Villanueva, A. ;
Boque, R. ;
Silva, P. ;
Carneiro, F. ;
Esteller, M. .
ONCOGENE, 2012, 31 (16) :2062-2074
[6]   Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker [J].
Elgaaen, Bente Vilming ;
Olstad, Ole Kristoffer ;
Haug, Kari Bente Foss ;
Brusletto, Berit ;
Sandvik, Leiv ;
Staff, Anne Cathrine ;
Gautvik, Kaare M. ;
Davidson, Ben .
BMC CANCER, 2014, 14
[7]   MiR-200, a new star miRNA in human cancer [J].
Feng, Xiangling ;
Wang, Zhengming ;
Fillmore, Rebecca ;
Xi, Yaguang .
CANCER LETTERS, 2014, 344 (02) :166-173
[8]   Modified Glasgow Prognostic Score is Associated With Risk of Recurrence in Bladder Cancer Patients After Radical Cystectomy A Multicenter Experience [J].
Ferro, Matteo ;
De Cobelli, Ottavio ;
Buonerba, Carlo ;
Di Lorenzo, Giuseppe ;
Capece, Marco ;
Bruzzese, Dario ;
Autorino, Riccardo ;
Bottero, Danilo ;
Cioffi, Antonio ;
Matei, Deliu Victor ;
Caraglia, Michele ;
Borghesi, Marco ;
De Berardinis, Ettore ;
Busetto, Gian Maria ;
Giovannone, Riccardo ;
Lucarelli, Giuseppe ;
Ditonno, Pasquale ;
Perdona, Sisto ;
Bove, Pierluigi ;
Castaldo, Luigi ;
Hurle, Rodolfo ;
Musi, Gennaro ;
Brescia, Antonio ;
Olivieri, Michele ;
Cimmino, Amelia ;
Altieri, Vincenzo ;
Damiano, Rocco ;
Cantiello, Francesco ;
Serretta, Vincenzo ;
De Placido, Sabino ;
Mirone, Vincenzo ;
Sonpavde, Guru ;
Terracciano, Daniela .
MEDICINE, 2015, 94 (42) :e1861
[9]   The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J].
Gregory, Philip A. ;
Bert, Andrew G. ;
Paterson, Emily L. ;
Barry, Simon C. ;
Tsykin, Anna ;
Farshid, Gelareh ;
Vadas, Mathew A. ;
Khew-Goodall, Yeesim ;
Goodall, Gregory J. .
NATURE CELL BIOLOGY, 2008, 10 (05) :593-601
[10]   Molecular biology - The expanding world of small RNAs [J].
Grosshans, Helge ;
Filipowicz, Witold .
NATURE, 2008, 451 (7177) :414-416
1234