Environmental Influences on Systemic Lupus Erythematosus Expression

被引：82
作者：
Kamen, Diane L. [1 ]
机构：
[1] Med Univ S Carolina, Dept Med, Div Rheumatol & Immunol, Charleston, SC 29425 USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2014年 / 40卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Systemic lupus erythematosus; Etiology; Vitamin D; Environment; Risk factors; EPSTEIN-BARR-VIRUS; VITAMIN-D DEFICIENCY; RHEUMATOID-ARTHRITIS; EPIGENETIC MECHANISMS; AUTOIMMUNE-DISEASES; MORTALITY PATTERNS; CIGARETTE-SMOKING; RISK-FACTORS; ASSOCIATION; PREVALENCE;
D O I：
10.1016/j.rdc.2014.05.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The etiology of systemic lupus erythematosus (SLE) is unknown, but multiple genetic, epigenetic, and environmental risk factors have been implicated. The inheritance of genes alone is not sufficient for developing SLE, suggesting the influence of environmental triggers on disease expression. Despite the tremendous amount of progress in elucidating potential environmental risk factors for SLE, much more needs to be done. An interdisciplinary approach to studies of the causes and, ultimately, prevention of SLE is needed. This article reviews what is understood about the relationship between environmental exposures and SLE, in addition to emerging areas of study.
引用
收藏
页码：401 / +
页数：13
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