Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats

被引：18
作者：
Ding, Rong [1 ,2 ]
Wang, Yue [3 ]
Zhu, Ji-Ping [4 ]
Lu, Wu-Guang [1 ,2 ]
Wei, Guo-Li [1 ,2 ]
Gu, Zhan-Cheng [5 ]
An, Zhen-Tao [6 ]
Huo, Jie-Ge [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Peoples R China
[2] Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210029, Peoples R China
[3] Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China
[4] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing 210023, Peoples R China
[5] Haimen City Hosp Tradit Chinese Med, Nantong 226100, Peoples R China
[6] 81 Hosp Peoples Liberat Army, Nanjing 210002, Peoples R China
来源：
JOURNAL OF INTEGRATIVE NEUROSCIENCE | 2020年 / 19卷 / 04期
关键词：
Oxaliplatin; peripheral neuropathy; neurotoxicity; electrophysiology; CELLS; ACTIVATION; NEURONS; PAIN; EXTRACT; PATHWAY; BRAIN; TRPA1; TRPV1;
D O I：
10.31083/j.jin.2020.04.1154
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.
引用
收藏
页码：663 / 671
页数：9
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