Genetic disorders of motor neurons

被引：16
作者：
Cole, N [1 ]
Siddique, T [1 ]
机构：
[1] Northwestern Univ, Sch Med, Dept Neurol, Chicago, IL 60611 USA
来源：
SEMINARS IN NEUROLOGY | 1999年 / 19卷 / 04期
关键词：
motor neuron disorders; spinal muscular atrophy; Kennedy disease; amyotrophic lateral sclerosis; neurodegeneration; genetics; genes;
D O I：
10.1055/s-2008-1040855
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Disorders of the motor neuron are etiologically and clinically heterogeneous and cause serious disability and death. Whereas mendelian inheritance can be demonstrated in a subset of these disorders, the genetic contribution to the sporadic forms of motor neuron degeneration are not well understood. In families with spinal muscular atrophy, Kennedy disease and amyotrophic lateral sclerosis, genetic linkage analysis and positional cloning have proven to be extremely productive. The genetics of these neurodegenerative disorders are reviewed.
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收藏
页码：407 / 418
页数：12
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