Acute toxicity of the aqueous extract of Erythrina velutina leaves in experimental animals

被引：8

作者：

Santos Craveiro, Ariadne Conceicao ^{[1
]}

Monteiro Carvalho, Deise Maria ^{[1
]}

Nunes, Rogeria de Souza

Fakhouri, Ricardo ^{[2
]}

Rodrigues, Sheila Alves ^{[3
]}

Teixeira-Silva, Flavia ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Fisiol, BR-49100000 Sao Cristovao, SE, Brazil

[2] Univ Fed Sergipe, Dept Med, BR-49060100 Aracaju, SE, Brazil

[3] Univ Tiradentes, Lab Prod Nat, BR-49032490 Aracaju, SE, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2008年 / 18卷

关键词：

Erythrina velutina; Fabaceae-Faboideae; mulungu; acute toxicity; phytotherapy;

D O I：

10.1590/S0102-695X2008000500018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acute toxicity of the aqueous extract of Erythrina velutina leaves in experimental animals. The aim of this work was to evaluate the acute toxicity of the aqueous extract of Erythrina velutina leaves, which is frequently used in folk medicine as a tranquilizer. The experimental design followed the Guide for Preclinical Toxicity Studies of Herbal Medicines from the Agencia Nacional de Vigilancia Sanitaria (Anvisa, 2004). Adult Wistar rats were treated per os with the limit dose of 5g/kg of the extract and then observed for 14 consecutive days. No animals died and no signs of toxicity were detected either during the behavioral observations or at the autopsies, what indicates a reasonable lack of toxicity for the extract.

引用

页码：739 / 743

页数：5

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